| 大鼠感染性脑损伤中神经细胞内游离钙的变化 |
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| 引用本文： | 陈翔,陈立华.大鼠感染性脑损伤中神经细胞内游离钙的变化[J].湖南医科大学学报,1998,23(4):353-355. |
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| 作者姓名： | 陈翔 陈立华 |
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| 摘 要： | 采用荧光法测定负载Ｆｕｒａ－２／ＡＭ大脑皮层突触体内游离钙「Ｃａ＾２＋」ｉ浓度大鼠感染性脑损伤中的变化及其意义。
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| 关 键 词： | 颅脑损伤 神经细胞 动物模型 游离钙 |
Alterations of intracellular free calcium concentration of cerebral neuronal cells in infectious brain injury in rats] |
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| X Chen,Y Yang,Y Tao,P Yu,L Chen.Alterations of intracellular free calcium concentration of cerebral neuronal cells in infectious brain injury in rats][J].Bulletin of Hunan Medical University,1998,23(4):353-355. |
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| Authors: | X Chen Y Yang Y Tao P Yu L Chen |
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| Institution: | Department of Pediatrics, Xiangya Hospital, Hunan Medical University, Changsha 410008. |
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| Abstract: | Intracellular free calcium concentration, Ca2+]i, of cerebral synaptosomes loaded by Fura-2/AM was measured by fluorescent method to clarify alterations of Ca2+]i in infectious brain injury (IBI) in rats. The results showed that Ca2+]i, water content (WC), and Evans blue content (EB) in groups injected by Bordetella pertussis suspension (BP) were increased compared to those in groups injected by normal saline (NS) at 0.5 h, 4 h, and 24 h, respectively. Increased Ca2+]i in BP groups showed time-dependent relationship and the highest level in the 24 h group. There was positive correlation (0.5 h, 4 h) and no correlation (24 h) between Ca2+]i and WC or EB. It is suggested that Ca2+]i accumulation of cerebral neuronal cells plays an important role in the pathogenetic mechanism of the acute and delayed IBI induced by BP. |
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