Tumor lysis syndrome following VP-16-213 in chronic myeloid leukemia in blast crisis

Several recent reports have emphasized the potentially serious and often fatal acute metabolic complications following cytotoxic chemotherapy in both solid tumors and leukemias. We present here a case of chronic myeloid leukemia in blast crisis who developed an acute tumor lysis syndrome following a single dose of VP-16-213 (Etoposide).