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Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice |
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| Authors: | Yamamoto, Satoshi Mitsumori, Kunitoshi Kodama, Yukio Matsunuma, Naochika Manabe, Sunao Okamiya, Hideaki Suzuki, Hiroshi Fukuda, Tatsuya Sakamaki, Yoshiyuki Sunaga, Masao Nomura, Gakushi Hioki, Kyoji Wakana, Shigeharu Nomura, Tatsuji Hayashi, Yuzo |
| Affiliation: | 1Department of Pharmacology, School of Medicine, Keio University Shinjuku-ku, Tokyo 160 2Central Institute for Experimental Animals Kawasaki, Kanagawa 216 3Biological Safety Research Center, National Institute of Health Sciences Setagaya-ku, Tokyo 158 4Laboratory Animal Science and Toxicology Laboratories, Sankyo Co. Ltd Fukuroi, Shizuoka 437 5Safety Research Laboratories, Yamanouchi Pharmaceutical Co. Ltd Itabashi-ku, Tokyo 170 6Preliminary Drug Evaluation Laboratory, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co. Ltd Gotemba, Shizuoka 412 7Preclinical Research Laboratories Inc. Kawasaki, Kanagawa 216, Japan |
| Abstract: | In this study, we investigated the carcinogenic response oftransgenic mice carrying the human prototype c-Ha-ras gene,namely Tg rasH2/CB6F1 mice, to various genotoxic carcinogensand compared it with that of control non-transgenic CB6F1 mice(non-Tg mice). The present studies were conducted as the firststep in the evaluation of the Tg rasH2/CB6F1 mouse as a modelfor the rapid carcinogenicity testing system. Short-term ( |
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