Triglyceride,albuminuria and blood pressure are the major associations of non-fatal cardiovascular disease in Chinese type 2 diabetes |
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Authors: | GTC Ko JCN Chan CC Chow VTF Yeung WB Chan WY So RCW Ma R Ozaki CS Cockram |
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Institution: | (1) Department of Medicine, Alice HML Nethersole Hospital, Tai Po, Hong Kong, HK;(2) Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T. Hong Kong, HK |
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Abstract: | Diabetes is associated with an increased risk of cardiovascular disease (CVD). We studied risk factors for CVD in a cohort
of Chinese type 2 diabetic patients recruited between July 1994 and August 1998. Ischemic heart disease (IHD) was defined
as a history of: (i) confirmed coronary artery disease (with typical electrocardiographic changes or a positive exercise tolerance
test) in patients under care of a cardiologist; (ii) documented myocardial infarction; or (iii) coronary interventions such
as angioplasty or coronary artery bypass graft. Cerebrovascular accident (CVA) was defined as any definite cerebral vascular
event with or without residual neurological deficit. CVD was defined as a history of IHD or CVA. The study enrolled 3333 patients,
including 1370 men (41.1%) and 1963 women (58.9%) of mean age 55.9±13.3 years (range, 16–91 years; median, 57 years). A total
of 279 patients (8.4%) had CVD (including 4.1% with CVA, 4.9% with IHD, and 0.6% with both CVA and IHD). Men had an overall
higher rate of CVD than women (10.1% vs. 7.1%, p=0.002). All cardiovascular diseases showed a progressive increase in prevalence with increasing age with the peak among those
aged ≤60 years. Logistic regression analysis was used to examine the predictive value of age, body mass index, waist-to-hip
ratio, blood pressure, fasting plasma glucose, glycated hemoglobin, lipid profiles, albuminuria, smoking and family history
of diabetes on the risk of CVD. In women, age, systolic blood pressure and triglyceride level and in men, age and albuminuria,
were predictive for CVD. In conclusion, 8.4% of Hong Kong Chinese type 2 diabetic patients being followed in a hospital out-patient
setting have a history of established and confirmed cardiovascular disease. Age, systolic blood pressure, triglyceride and
albuminuria were the major independent risk factors for non-fatal cardiovascular diseases.
Received: 30 January 2002 / Accepted in revised form: 15 October 2002
Correspondence to G.T.C Ko |
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Keywords: | Cardiovascular diseases Risk factors Chinese Type 2 diabetes |
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