Effects of sintered apatite on bone regeneration in rabbits |
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| Affiliation: | 1. Department of Materials Engineering and Center for Thin Film Technologies and Applications, Ming Chi University of Technology, Taipei 243, Taiwan;2. Institute of Materials Science and Engineering, National Taiwan University, Taipei 106, Taiwan |
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| Abstract: | Apatite is considered to be effective for bone regeneration when it contains calcium carbonate and β-TCP. In the present study, we made 3 different apatite preparations, hydroxyapatite, hydroxyapatite containing calcium carbonate, and hydroxyapatite containing β-TCP, using spark plasma sintering and compared their abilities for osteoinduction. For elucidation of bone regeneration, evaluations are generally made after euthanasia of experimental animals. However, the present R_mCT® procedure allowed such evaluations while the animals were alive. Our results showed that sintered HAP containing β-TCP was more effective for guided bone regeneration than the other test materials. |
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| Keywords: | Apatite Bone regeneration Calcium carbonate Micro-CT |
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