Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive–compulsive disorder patients |
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| Institution: | 1. Psychotic Disorders Program, UMass Memorial Medical Center/University of Massachusetts Medical School, Worcester, MA, United States;2. Department of Psychiatry, Tianjin Medical University, Tianjin, China;3. First Affiliated Hospital/Zhengzhou University, Zhengzhou, China;4. Partners Community Healthcare, Inc., Haverhill, MA, United States;5. Department of Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States;6. Schizophrenia Program, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States;7. Department of Psychiatry, New York University Medical School, New York, NY, United States;1. Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa;2. Centre for Statistical Consultation, Stellenbosch University, South Africa;3. Division of Neurology, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa;4. Department of Psychiatry, University Medical Centre Utrecht, The Netherlands;1. Department of Psychiatry, Dalhousie University, Nova Scotia, Canada;2. Robarts Research Institute, University of Western Ontario, Ontario, Canada;3. Biomedical Translational Imaging Centre, Halifax, Nova Scotia, Canada;4. Department of Biomedical Engineering, University of Alberta, Alberta, Canada;5. Faculty of Computer Science, Department of Psychology and Neuroscience, Dalhousie University, Nova Scotia, Canada |
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| Abstract: | Numerous neuroimaging studies have suggested that obsessive–compulsive disorder (OCD) patients had a neurobiological abnormality in the frontal-subcortical circuits. On the other hand, there are distinct differences in the responses to pharmacological treatment among OCD patients. In the present study, we measured the concentration of N-acetyl aspartate (NAA), a putative marker of neuronal viability, with proton magnetic resonance spectroscopy (MRS) in OCD patients with different pharmacological responses. Participants comprised 20 patients and 26 healthy control subjects. OCD patients were divided into three groups according to the pharmacological response; responders to a selective serotonin reuptake inhibitor (SSRI) (group A: n = 7), responders to SSRI with an atypical antipsychotic (group B: n = 8) and non-responders to either SSRI or SSRI with an atypical antipsychotic (group C: n = 5). Short echo proton MRS was used to measure NAA concentrations in the anterior cingulate, the left basal ganglia and the left prefrontal lobe of subjects. A significantly lower NAA concentration was observed only in group B compared with control subjects in the anterior cingulate. Our results suggest that a subgroup of OCD patients who respond to an SSRI with an atypical antipsychotic have distinct biological abnormalities in the anterior cingulate. |
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