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A randomized controlled trial by the 3DS for dental caries
Institution:1. Piracicaba Dental School, University of Campinas – UNICAMP, Department of Restorative Dentistry, Av. Limeira 901, Piracicaba, SP 13414-903, Brazil;2. Institute of Dentistry, University of Oulu, and Medical Research Center Oulu, Oulu University Hospital, PO Box 5281, 90014 University of Oulu, Finland;3. Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Hospital, Helsinki, Finland;4. Piracicaba Dental School, University of Campinas – UNICAMP, Department of Morphology, Av. Limeira 901, Piracicaba, SP 13414-903, Brazil;5. Piracicaba Dental School, University of Campinas – UNICAMP, Department of Restorative Dentistry, SP 13414-903, Brazil;1. Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA;2. Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China;3. State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, China;4. Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA;5. Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA;6. Department of Mechanical Engineering, University of Maryland, Baltimore County, MD 21250, USA;1. Department of Orthodontics, Peking University School and Hospital of Stomatology, China;2. Department of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, China;3. School of Information and Electronics, Beijing Institute of Technology, China;1. Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita 565-0871, Japan;2. The Japan Health Care Dental Association, 1-45-15 Sekiguchi, Bunkyo-ku, Tokyo 112-0014, Japan;1. Assistant Professor, Department of Conservative Dentistry & Endodontics, King George''s Medical University, Lucknow, India;2. Assistant Professor, Department of Paediatric & Preventive Dentistry, King George''s Medical University, Lucknow, India;3. Assistant Professor, Department of Periodontology, King George''s Medical University, Lucknow, India;4. Assistant Professor, Department of Prosthodontics, King George''s Medical University, Lucknow, India;5. Professor, Department of Conservative Dentistry & Endodontics, King George''s Medical University, Lucknow, India;1. Functional Anatomy Research Center (FARC), Laboratorio di Anatomia Funzionale dell’Apparato Stomatognatico, Dipartimento di Scienze Biomediche per la Salute, Facoltà di Medicina e Chirurgia, Università degli Studi di Milano, via Luigi Mangiagalli 31, 20133 Milano, Italy;2. Dipartimento di Scienze Biomediche per la Salute, Facoltà di Medicina e Chirurgia, Università degli Studi di Milano, via Luigi Mangiagalli 31, 20133 Milano, Italy;3. Private practice, SST Dental Clinic, via Martiri della Libertà 58, 20090 Segrate, MI, Italy
Abstract:The aim of this study is to evaluate the povidone-iodine for the suppression of oral cariogenic bacteria and compare its effects to that of fluoride in children. We carried out a randomized controlled trial to compare the effects of povidone-iodine to those for sodium fluoride. Pre-school children (n = 210) with more than 105 cfu/ml mutans streptococci in their stimulated saliva were randomly sampled and randomly allocated into three groups. We planned the preventive program by 3DS (Dental Drag Delivery System). The groups that provided preventive programs were the povidone-iodine group (n = 70) and the sodium fluoride group (n = 70). A control group (n = 70) received no intervention. Povidone-iodine or sodium fluoride was applied to the tooth surface using custom made trays. Subsequent home care was obligatory for one month. After one month, the salivary levels of mutans streptococci were low level when compared to the based data. However the difference in salivary levels of mutans streptococci among groups was not statistically significant when comparing the povidone-iodine group with the sodium fluoride group (P = 0.625). After 2.5 years follow up, differences in incidence of new dental caries among the three groups were not statistically significant (P = 0.583). Clinical application of anti-microbial drugs may be effective, but only a single intervention is not sufficient to reduce the incidence of new dental caries.
Keywords:Anti-microbial drugs  Dental drug delivery system  Incidence of dental caries  Mutans streptococci  Randomized controlled trial
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