不同稀释浓度的痰热清注射液对急性上呼吸道感染患儿的疗效与安全性影响

目的:考察不同稀释浓度的痰热清注射液对儿童急性上呼吸道感染(children with acute upper respiratory tract infection,AURTI)的疗效与安全性。方法:抽取2018年1月—12月间收治的采用痰热清注射液治疗的AURTI患儿108例资料,按照痰热清注射液的稀释浓度不同将其分为高浓度组29例、中浓度组40例和低浓度组39例;分析不同痰热清注射液的稀释浓度对各组患儿的临床症状复常时间、总有效率和用药期间不良反应发生率差异。结果:高、中浓度组患儿用药后症状和体征的恢复时间相当(<5 d),但早于低浓度组(<7 d);高、中浓度组用药后的总有效率分别为89.66%和87.50%,经两组间比较其差异无统计学意义(P>0.05),但均显著高于低浓度组(64.10%);中、低浓度组患儿治疗期间不良反应发生率分别为7.50%和5.13%,经两组间比较其差异无统计学意义(P>0.05),但均显著低于高浓度组(31.03%)。结论:痰热清注射液不同稀释浓度对治疗AURTI患儿的疗效和安全性影响较大;适当稀释痰热清注射液的浓度不仅具有良好的临床疗效,而且安全性较高。

Influence of Tanreqing Injection with Different Concentrations on Efficacy and Safety in Children with AURTI

Objective:To investigate the influence of Tanreqing injection with different dilution concentrations on efficacy and safety in children with acute upper respiratory tract infection(AURTI).Methods:108 children with AURTI who were treated with Tanreqing injection from January to December 2018 were selected.According to the different dilution concentration of Tanreqing injection,29 patients in the high concentration group,40 patients in the medium concentration group and 39 patients in the low concentration group were divided into the high concentration group,the meddle concentration group and the low concentration group.The differences of the dilution concentration of Tanreqing injection on the recurrence time of clinical symptoms,the total effective rate and the incidence of adverse drug reactions(ADRs)during administration were analyzed.Results:The recovery time of symptoms and signs in the high and meddle concentration group was similar(<5 d),but earlier than that in the low concentration group(<7 d).The total effective rate was 89.66%and 87.50%respectively in the high concentration group and the meddle concentration group,and the difference between the two groups was not statistically significant(P>0.05),but significantly higher than that in the low concentration group(64.10%).The incidence of ADRs during treatment was 7.50%and 5.13%,respectively,in the meddle and low concentration groups.The difference between the two groups was not statistically significant(P>0.05),but significantly lower than that in the high concentration group(31.03%).Conclusion:The efficacy and safety of Tanreqing injection in patients with AURTI were significant.Proper dilution of Tanreqing injection has not only good clinical effect but also higher safety.