槐果碱和氧化槐果碱抗肿瘤药理作用的研究进展

经体外实验发现,槐果碱能浓度相关地抑制肝癌细胞(HepG2、9711、SMMC-7721、HCC-LM3、MHCC-97H)、大肠癌(SW480、LS174t、SW620、HCT-116)以及食管癌EC109、胃癌BGC823、白血病(K562、HL-60)、淋巴瘤U937、肺癌A549、神经胶质瘤C6、卵巢癌(SKOV3、PM-2)等细胞的增殖。氧化槐果碱可抑制HepG2、SW480、LS174t、BGC823、C6、乳腺癌MCF-7等细胞的增殖。整体实验结果发现,槐果碱能抑制HCC-LM3、肉瘤W256、S37、S180、EAC、Lio 1、白血病615(L615)、宫颈癌14(U14)等细胞移植瘤在小鼠或大鼠体内的生长。临床上槐果碱还可用于治疗恶性葡萄胎。文中综述槐果碱和氧化槐果碱抗肿瘤细胞作用的文献,并对其研究进展做了分析。

Research Advances on Pharmacological Effects of Sophocarpine and Oxysophocarpine Against Tumors

Sophocarpine inhibits proliferation in association with dosage on hepatoma(HepG2,9711,SMMC-7721,HCC-LM3,MHCC-97 H)cell,large intestine carcinoma(SW480,LS147 t,SW620,HCT-116) cell,carcinoma of esophagus EC109 cells,gastric carcinoma BGC823 cells,leukemia K562 cells,HL-60 cells,lymphoma U937 cells,lung cancer A549 cells,neuroglioma C6 cells,ovarian carcinoma SKOV3 cells,PM-2 cells in vitro. Oxysophocarpine inhibits proliferation in association with dosage on HepG2,SW480,LS174 t,BGC823,C6 cells and mammary cancer MCF-7 cells in vitro. Sophocarpine has the effects of inhibiting transplant growth of HCC-LM3 cells,sarcoma W256,S37,S180,EAC,Lio 1,leukemia L615 and cervical carcinoma U14 cells in mice or rats in vivo. Clinically,Sophocarpine can also be used to treat malignant hydatidiform mole. In this paper,the literature on the antitumor effects of sophocarpine and oxysophocarpine on tumor cells were reviewed,and the research progress was analyzed.