Collagen platelet receptor polymorphisms integrin α2β1 C807T and GPVI Q317L and risk of ischemic stroke |
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| Authors: | V. J. Cole,J. M. Staton,J. W. Eikelboom &dagger ,G. J. Hankey&dagger &Dagger ,Q. Yi§ ,Y. Shen,M. C. Berndt, R. I. Baker &dagger |
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| Affiliation: | Thrombosis and Haemophilia Unit, Royal Perth Hospital, Perth, Australia;;Department of Medicine, University of Western Australia;;Stroke Unit, Department of Neurology, Royal Perth Hospital, Perth, Australia;;Biostatistics Department, Princess Margaret Hospital, Toronto, Canada;;and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia |
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| Abstract: | Summary. Several polymorphisms of integrin α2β1 and glycoprotein (GP) VI that may modify platelet–collagen interactions or subsequent signaling have been described. We conducted a case-control study involving 180 stroke patients and 172 controls to determine whether the α2 C807T and GPVI Q317L polymorphisms were associated with an increased risk of ischemic stroke. We found no statistically significant differences in the distribution of α2 C807T and GPVI Q317L in patients and controls overall or after stratification by etiological subtype. The GPVI 317QQ genotype was found to be over-represented in a subgroup of patients ≥60 years compared to corresponding controls. However, this association did not remain significant after adjustment for other cardiovascular risk factors. Our results do not support a role for the integrin α2 C807T and GPVI Q317L polymorphisms in the development of first-ever ischemic stroke. However, larger studies are required to confirm this. |
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| Keywords: | glycoprotein VI ischemic stroke integrin α2β1 collagen receptors polymorphisms |
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