溃疡性结肠炎患者血清超氧化物歧化酶及脂质过氧化物的变化

用黄嘌呤氧化法及硫代巴比妥酸反应产物比色法分别对120例溃疡性结肠炎患者血清超氧化物歧化酶（SOD）及脂质过氧化物（LPO）含量进行检测。结果表明：溃疡性结肠炎患者SOD明显低于对照组（P＜0．001）；LPO明显高于对照组（P＜0．001）。其中单纯湿热内蕴型或兼胃虚弱型或兼脾虚气滞血瘀型或兼阴虚气滞血瘀型血清SOD含量均明显低于对照组（P＜0．001）；而血清LPO含量均明显高于对照组（P＜0．001）。结果提示：以湿热内蕴型为主的溃疡性结肠炎患者清除氧自由基，保护细胞免受损伤的SOD降低，而间接反映细胞损伤的LPO升高。当伴有虚证时，尤以脾胃虚弱型或脾虚气滞血瘀型的溃疡性结肠炎患者SOD含量明显降低和LPO含量明显增高。

Changes of superoxide dismutase and lipid peroxide in blood serum ulcerative of colitis patient

The content of superoxide dismutase (SOD) and lipid peroxide (LPO) of blood serum in 120 ulcerative colitis (UC) patient were tested by means of xanthine oxidation method and colorimeter on the reactive product of thio-barbituric acid. The content of SOD in the UC Patients was lower than that in the normal control group ( P <0.001), and the content of LPO in the UC patients was obviously higher than that the control group ( P <0.001). The content of SOD in the UC patients which accompanied the types of simple retention of damp-heat in the interior or weakness of the spleen and the stomach or the stagnancy of qi and blood stasis or deficiency of yin and stagnancy of qi and blood stasis was distinctly lower tban the one in the normal control groups ( P <0.001). The content of LPO in them is distinctly higher than the content of LPO in normal control group ( P <0.001). Conclusion: These results suggested that the content of SOD of protecting cell factor in the body of ulcerative colitis patients who were mostly the type of retention of damp-heat in the interior decreased and the content of LPO of damaging cell factor increased. When the patients accompanied with the deficiency, the content of the SOD in them reduced remarkably and the content of LPO enhanceed remarkably, especially in those who are the type of weekness of the spleen and the stomach or insufficiency of the spleen and the stagnancy of qi and blood stasis.