Cardiac isoform of alpha-2 macroglobulin as a novel diagnostic marker for cardiac diseases. |
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| Authors: | Andiappan Rathinavel Perundurai S Dhandapany Ponnambalam Annapoorani Subbiah Ramasamy Govindan Sadasivam Selvam |
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| Institution: | Department of Cardio-Thoracic Surgery, Madurai Medical College and Government Rajaji Hospital, Madurai, Tamil Nadu, India. biochemselvam@rediffmail.com |
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| Abstract: | BACKGROUND: Earlier we showed cardiac isoform of alpha-2 macroglobulin (CA2M) to be an early marker of cardiac hypertrophy. DESIGN: In this study, we tried to explore the possibility of using this protein as a marker for diagnosis of cardiac diseases. METHODS: A total of 593 samples were analyzed for the presence of CA2M using sandwich enzyme-linked immunosorbent assay. RESULTS: Samples include various cardiac diseases (230), non-cardiac ailments (263) and controls (100). CONCLUSION: Levels of CA2M in cardiac diseases were significantly higher than other sample groups but moderately elevated in leprosy. This protein could be considered for diagnosis of cardiac diseases as a serum marker. |
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