| 灯盏花对脑缺血神经元凋亡的防治作用 |
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| 引用本文： | 陈康宁,董为伟.灯盏花对脑缺血神经元凋亡的防治作用[J].中国临床神经科学,2000,8(1):5-7. |
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| 作者姓名： | 陈康宁 董为伟 |
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| 作者单位： | 1. 重庆市西南医院神经内科,400038
2. 重庆医科大学神经病学研究所,400016 |
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| 基金项目： | 国家自然科学基金资助项目．No．39670269 |
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| 摘 要： | 目的探讨蛋白激酶C抑制剂灯盏花注射液对神经元凋亡的防治作用。方法采用大鼠全脑缺血模型，观察脑缺血／再灌流后蛋白激酶C活性、神经元凋亡的变化及灯盏花对上述的影响。结果脑缺血／再灌流可以导致蛋白激酶C的移位激活、神经元凋亡的增加。灯盏花可以阻止脑缺血／再灌流导致的上述变化。结论灯盏花注射液对脑缺血／再灌流导致神经元凋亡有防治作用。
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| 关 键 词： | 神经元凋亡 蛋白激酶C 脑缺血／再灌流 灯盏花 |
| 修稿时间： | 1993-03-11 |
Effect of Dengzhanhua on Neuronal Apoptosis Induced by Cerebral lschemia |
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| CHEN Kong-Ning,DONG Wei-Wei.Effect of Dengzhanhua on Neuronal Apoptosis Induced by Cerebral lschemia[J].Chinese Journal of Clinical Neurosciences,2000,8(1):5-7. |
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| Authors: | CHEN Kong-Ning DONG Wei-Wei |
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| Institution: | CHEN Kong-Ning
,DONG Wei-Wei
(Department of Neurology South-West Hospital (400038)) |
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| Abstract: | Aim: To observe the effect of protein kinase C (PKC) inhibitor (Dengzhanhua injection) on neuronal apoptosis induced by cerebral ischemia/reperfusion. Methods: After the model ischemia/reperfusion was established in male Wistar rat. the changes of PKC activity and neuronal apoptosis were observed, the effect of Dengzhanhua injection on the above was also observed. Results: Cerebral ischemia/reperfusiun could result in PKC translocational activation and neuronal apoptosis. Dengzhanhua injection could prevent above change induced by cerebral ischemia/reperfusion. Conclusion: PKC inhibitor could prevent neuronal apoptosis induced by cerebral ischemia/reperfusion. |
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| Keywords: | neuronal apoptosis protein kinase C cerebral ischemia/reperfusion Dengzhanhua |
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