| 不同临床分期2型糖尿病肾病尿液色素上皮衍生因子表达 |
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| 引用本文： | 曹卫广,;刘珊,;王战建. 不同临床分期2型糖尿病肾病尿液色素上皮衍生因子表达[J]. 临床误诊误治, 2014, 0(8): 99-101 |
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| 作者姓名： | 曹卫广, 刘珊, 王战建 |
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| 作者单位： | [1]河北省优抚医院内三科,石家庄050000; [2]石家庄市第二医院内分泌科,石家庄050051; [3]河北医科大学第三医院内分泌科,石家庄050051 |
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| 基金项目： | 河北省科技厅科技支撑项目（12277795） |
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| 摘 要： | 目的观察不同临床分期的2型糖尿病肾病(diabetic nephropathy,DN)尿液色素上皮衍生因子(PEDF)水平及其与病情严重程度的关系。方法选择2型糖尿病120例,根据病情分为单纯糖尿病组、DNⅢ期组、DNⅣ期组和DNⅤ期组4组,每组30例;另选择同期健康体检者30例作为对照组,观察比较5组尿液PDEF水平。结果尿液PDEF水平对照组为(1.13±0.39)μg/ml,单纯糖尿病组为(4.57±0.47)μg/ml,DNⅢ期组为(6.88±0.79)μg/ml,DNⅣ期组为(8.52±0.77)μg/ml,DNⅤ期组为(5.70±0.64)μg/ml。与对照组比较,单纯糖尿病组、DNⅢ期组、DNⅣ期组和DNⅤ期组尿液PDEF水平均升高,差异均有统计学意义(P0.05);单纯糖尿病组、DNⅢ期组和DNⅣ期组随病情严重程度增加尿液PDEF水平升高,3组间两两比较差异亦均有统计学意义(P0.05);DNⅤ期组尿液PEDF水平显著低于DNⅢ期组和DNⅣ期组,但高于单纯糖尿病组,差异亦均有统计学意义(P0.05)。结论DN患者尿液PEDF水平变化出现于病变早期,并且随着病情进展逐渐改变。尿液PEDF可作为早期诊断DN的一个敏感性指标。
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| 关 键 词： | 2型糖尿病 糖尿病肾病 尿 色素上皮衍生因子 |
Expression of Pigment Epithelium-Derived Factor at Different Stages of Type 2 Diabetic Nephropathy |
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| Affiliation: | CAO Wei-guang , LIU Shan , WANG Zhan-jian ( 1. The Third Department of Internal Medicine, Special Care Hospital of Hebei Province, Shijiazhuang 050000, China; 2. Department of Endocrinology, The Second Hospital of Shijiazhuang City, Shijiazhuang 050051, China; 3. Department of Endocrinology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China) |
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| Abstract: | Objective To observe the expression level of urinary pigment epithelium-derived factor （ PEDF） at differ-ent stages of type 2 diabetic nephropathy （ DN） and its relationship to disease condition. Methods 120 type 2 diabetic pa-tients were divided into four groups（30 patients per group）, including simple diabetes mellitus group （T2DM group）, type 2 diabetic nephropathy stage Ⅲ group（ DN Ⅲ group） , type 2 diabetic nephropathy stage Ⅳ group（ DN Ⅳ group） , and type 2 diabetic nephropathy stageⅤgroup（ DNⅤgroup） . 30 healthy people with medical examinations at the same time were chosen as control group. Urinary PEDF in the 5 groups were detected for comparisons. Results The urinary PEDF was （1. 13 ±0.39）μg/ml in control group, （4. 57 ±0. 47）μg/ml in T2DM group, （6. 88 ±0. 79）μg/ml in DNⅢ group, （8. 52 ±0. 77）μg/ml in DNⅣ group and （5. 70 ±0. 64）μg/ml in DNⅤgroup, respectively. PEDF level in T2DM group, DNⅢgroup, DNⅣgroup and DNⅤgroup was significantly higher than that in the control group（P〈0.05）,and it increased with the severity of the disease in T2DM group, DNⅢgroup and DNⅣgroup, and the differences among the 3 groups were significant （P〈0.05）. PEDF level in DNⅤ group was lower than that in DNⅢ group and DNⅣ group, but higher than that in T2DM group, and the differences were significant （ P〈0.05 ） . Conclusion The urinary PEDF level in patients with diabetic ne-phropathy may change in early phase and change gradually with progression of disease. It can be a sensitive marker in diagno-sing diabetic nephropathy at early stage. |
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| Keywords: | Type 2 diabetes mellitus Diabetic nephropathy Urine Pigment epithelium-derived factor |
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