| 白芍总甙对大白鼠睡眠节律的影响 |
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| 引用本文： | 张安平,陈敏珠.白芍总甙对大白鼠睡眠节律的影响[J].中国药理学通报,1993,9(6):454-457. |
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| 作者姓名： | 张安平 陈敏珠 |
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| 作者单位： | 安徽医科大学临床药理研究所 合肥230032
(张安平，陈敏珠)，安徽医科大学临床药理研究所 合肥230032(徐叔云) |
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| 摘 要： | 白芍总甙(TGP)每日ig 50mg·kg~(-1),连续7d可延长正常大鼠慢波睡眠(SWS)的持续时间.并能使咖啡因(12.5 mg·kg~(-1),ip)诱导的失眠大鼠睡眠各参数恢复到接近正常水平。TGP 50mg·kg~(-1)×3d)还可明显延长游泳大鼠(水温25±1℃.游泳时间30min)SWS和异相睡眠的总时间。上述实验结果提示TGP可改善不同功能状态下的大鼠睡眠。
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| 关 键 词： | 白芍总甙 脑电图 肌电图 慢波睡眠 异相睡眠 |
Effects of total glucosides of paeony on sleep-waking rhythm in rats |
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| ZHANG An-Ping,CHEN Min-Zhu,XU Shu-Yun.Effects of total glucosides of paeony on sleep-waking rhythm in rats[J].Chinese Pharmacological Bulletin,1993,9(6):454-457. |
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| Authors: | ZHANG An-Ping CHEN Min-Zhu XU Shu-Yun |
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| Abstract: | Total glucosides of paeony (TGP, 50 mg/kg 7d, ig) could enhance the episode duration of slow-wave sleep (SWS) in normal rats, and restore the sleep parameters in the insomniac rats induced by caffeine ( 1 2. 5 mg/kg 7 d,ip)nearly to the normal level. It (50 mg/kg 3 d,ig) also increased significantly the
total time of SWS and paradoxical sleep (PS) in the swimming rats (water temperature 25±1℃, swimming time 30 min). These results suggest that TGP probably improve the sleep of rats under the different states. |
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| Keywords: | TGP EEG EMC SWS PS |
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