Etiological investigation of fatal liver failure during the course of chronic hepatitis B in southeast China |
| |
Authors: | Wei-Min Ke Xue-Jun Li Li-Na Yu Jing Lai Xiao-He Li Zhi-Liang Gao Pei-Jia Chen |
| |
Institution: | (1) Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat-Sen University, Shipai, Guangzhou, 510630, P. R. China;(2) Response Genetics, Los Angeles, CA 90033, USA |
| |
Abstract: | Background The purpose of this study was to clarify the relationships between patients who had fatal liver failure during the course
of chronic hepatitis B and those who were also superinfected with hepatitis A, C, D, or E virus, as well as their hepatitis
B virus e system status, so that suitable measures could be adopted to decrease the mortality of patients with chronic hepatitis
B.
Methods This study detected superinfections of hepatitis A, C, D, or E virus and the hepatitis B virus e system status in cases of
fatal liver failure during the course of chronic hepatitis B by enzyme-lined immunosorbent assay.
Results The frequency of superinfections of hepatitis A, C, D, and E virus was 1.4% (4/282), 6.4% (18/282), 1.8% (5/282), and 28.4%
(80/282), respectively, overall, 37.9% (107/282). Hepatitis E was prominent and steady in superinfection rates during the
past 12 years. In 62.1% (175/282) of patients, the causes of fatal liver failure were not clear. The serological status frequency
of HBeAg(+) and anti-HBe(−), HBeAg(−) and anti-HBe(−), and HBeAg(−) and anti-HBe(+) was 20.6% (22/107), 23.4% (25/107), and
56.1% (60/107), respectively, in the group with superinfections of hepatitis A, C, D, or E virus and 31.4% (55/175), 21.1%
(37/175), and 47.4% (83/175), respectively, in the group in which causes were not clear. The serological status HBeAg(+) and
anti-HBe(−) was more frequent in the group in which causes were not clear than in the group with superinfections of hepatitis
A, C, D, or E virus (P < 0.05). Statistically, there were no differences (P > 0.05) between the serological status HBeAg(−), anti-HBe(−) and HBeAg(−), anti-HBe(+) between the two groups.
Conclusions These results suggest that superinfection (107/282) is an important factor in fatal liver failure. The mortality of chronic
hepatitis B can be decreased by strict food sanitation and the use of safe blood products. There were no significant relationships
between hepatitis B e antigen seroconversion and fatal liver failure during the course of chronic hepatitis B. |
| |
Keywords: | chronic hepatitis B fatal liver failure superinfection hepatitis B virus e system status |
本文献已被 PubMed SpringerLink 等数据库收录! |
|