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| 兰索拉唑抗实验性胃溃疡作用的研究 | |
| 引用本文： | 许华,俞励平,文洁,赵文,黄亚东,李校堃.兰索拉唑抗实验性胃溃疡作用的研究[J].中国病理生理杂志,2002,18(6):698-700. |
| 作者姓名： | 许华 俞励平 文洁 赵文 黄亚东 李校堃 |
| 作者单位： | 1. 暨南大学医药生物技术研究开发中心, 广东广州 510632; 2. 中山医科大学药物开发中心, 广东广州 510080 |
| 摘 要： | 目的:研究注射用兰索拉唑对大鼠实验性胃溃疡的影响。方法:采用大鼠出血休克性胃溃疡、水浸应激性胃溃疡及幽门结扎性胃溃疡模型,观察兰索拉唑静脉注射对损伤胃粘膜的保护作用。结果:兰索拉唑15-60 mg/kg事先给药,对3种胃溃疡模型都有明显的抑制溃疡形成作用,且有良好的量效关系。在同等剂量下兰索拉唑和奥美拉唑的抗溃疡作用无显著差异,但对水浸应激性胃溃疡的疗效明显强于后者(P＜0.01)。结论:兰索拉唑静脉注射明显抑制大鼠实验性胃溃疡的形成。 |
| 关 键 词： | 兰索拉唑 休克 出血性 胃溃疡 应激 大鼠 |
| 文章编号： | 1000-4718(2002)06-0698-03 |
| 收稿时间： | 2002-03-20 |
| 修稿时间： | 2002年3月20日 |
Effect of lansoprazole on gastric ulceration in rats |
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| XU Hua ,YU Li-ping ,WEN Jie ,ZHAO Wen ,HUANG Ya-dong ,LI Xiao-kun.Effect of lansoprazole on gastric ulceration in rats[J].Chinese Journal of Pathophysiology,2002,18(6):698-700. | |
| Authors: | XU Hua YU Li-ping WEN Jie ZHAO Wen HUANG Ya-dong LI Xiao-kun |
| Institution: | 1. Biopharmaceutical R&D Center of Jinan University, Guangzhou 510632, China; 2. Drug R&D Center of Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China |
| Abstract: | AIM:To investigate the effect of lansoprazole on gastric ulceration in rats. METHODS:Using the gastric ulcer model induced by hemorrhagic shock, restraint water-immersion stress and pylorus-ligature, the protective effect of lansoprazole (iv) on gastric ulceration was observed. RESULTS: Pretreatment with lansoprazole (7.5-60 mg/kg) significantly inhibited the formation of gastric ulcer in the three models in a dose-dependent manner. The autiulcer efficacy of lansoprazole was similar to that of omeprazole in the equal dose, but stronger than that of omeprazole for ulcer induced by water-immersion stress. CONCLUSION: The intravenously administered lansoprazole inhibited formation of experimental gastric ulcer in rats. |
| Keywords: | Lansoprazole Shock hemorrhagic Stomach ulcer Stress Rats |
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