广东省顺德市原发性肝癌危险因素流行病学研究

为探讨广东省顺德市原发性肝癌可能的发病因素,我们调查了96例原发性肝癌病例及按年龄、性别等齐同原则以1:1.5配医院对照144例作为对照组。对所有调查者采用统一调查表直接询问可能的发病因素91个,并采用静脉血检测HBV和HCV的血清学标志。结果表明:顺德市原发性肝癌的发生与HBV感染密切相关,本人肝炎史、饮酒史以及食生鱼肉或生虾史、食腌咸鱼史等均为原发性肝癌发生的主要危险因素。讨论了原发性肝癌的发生与HBV和HCV合并感染的协同作用,值得进一步研究。

An Epidemiologic Study on the Aetiological Factors of Primary Liver Cancer in Shunde City of Guangdong Province

In order to investigate the aetiological factors of Primary Liver Cancer (PLC)in Shunde City of Guangdong province, 96 clinically diagnosed PLC patients and 144 matched hospital controls were interviewed and their blood samples were examined for HBV, HCV and other seven indices. Monofactorial and multifactorial analyses were fitted by using Non-conditional Logistic Regression model. The findings confirmed the strong association between HBV infection and PLC. Histories of hepatitis and histories of eating raw fish,shrimp or salt fish were also noticed. The history of alcohol intake might have associated with PLC. The present study did nor find associations between PLC and drinking water, histories of blood transfusion and injection or exposure to insecticides. Antibody of HBV surface antigen seemed to be a protective factor with a relative risk of 0.3064 (0.1617-0.5701). The results showed that the combined effects of HBsAg infection and HCV infection were worthy for further study.