HBsAg慢性携带者的遗传流行病学研究

对23个HBsAg慢性携带者家系375人进行遗传流行病学研究结果显示:有血缘关系亲属HBsAg携带率明显高于无血缘关系者(P<0.01);且1、2、3级亲属间随血缘关系疏远携带率递减(P<0.01)。有共同生活史者携带率>无共同生活史者(P<0.01)。但HBV感染另二项指标抗-HBs和抗-HBc都不显示以上差别。经叉生分析和Logistic回归多因素分析,均证明血缘关系在HBsAg携带上起重要作用,共同生活也有联系。1、2、3级亲属加权平均遗传度为88.80%。经遗传方式分析,排除了单基因遗传病的可能,符合多基因遗传病特点。

A Genetic Epidemiologic Study on HBsAg Chronic Carriers

375 individuals from 23 HBsAg positive families were investigated in the study. The results showed that HBsAg carrier rate among blood relatives was significantly higher than nonblood relatives (P<0.01); HBsAg carrier rate decreased with the order of the first, second and third degree relatives (P<0.01); and the rate in the individuals living together with the probands was higher than those living apart (P<0.01). However,the other two markers of HBV infectivity, anti-HBs and anti-HBc, did not show any differences mentioned above. The results analysed by means of dichotomy and Logistic regression model, showed that blood relationship played an important role in HBsAg carrier state. In addition, the history of sharing living facilities was related to HBsAg carrier state. The average heritability in the first, second and third degree relatives was 79.68%. The analysis of genetic model showed that HBsAg carrier state was corresponded to the characteristic of multifactorial genetic disease, excluding the possibility of genetic disease due to single gene.