Semantic memory impairment in temporal lobe epilepsy associated with hippocampal sclerosis |
| |
| Authors: | Messas Cristiane Stravino Mansur Letícia Lessa Castro Luiz Henrique Martins |
| |
| Affiliation: | 1. Department of Psychology, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada;2. Department of Psychology, University of Toronto Mississauga, Mississauga, Canada;3. Neurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, Canada;1. Faculty of Psychology, Autonoma University of Madrid, Madrid, Spain;2. Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London, UK;3. University Hospital of San Carlos, Epilepsy Unit, Neurology Department, Madrid, Spain;4. Hospital Ruber Internacional, Epilepsy Unit, Neurology Department, Madrid, Spain;1. Dept. of Epileptology, University of Bonn Medical Center, Sigmund-Freud-Str. 25, 53105 Bonn, Germany;2. Dept. of Neurosurgery, University of Bonn Medical Center, Sigmund-Freud-Str. 25, 53105 Bonn, Germany;3. Dept. of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Str. 25, 53105 Bonn, Germany;1. Department of Psychology, University of Toronto, Toronto, Ontario, Canada;2. Department of Psychology, Hospital for Sick Children, Toronto, Ontario, Canada;3. Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada;4. Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada;5. Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada |
| |
| Abstract: | Episodic memory impairment is a well-recognized feature of mesial temporal lobe epilepsy. Semantic memory has received much less attention in this patient population. In this study, semantic memory aspects (word-picture matching, word definition, confrontation and responsive naming, and word list generation) in 19 patients with left and right temporal lobe epilepsy secondary to mesial temporal sclerosis (MTS) were compared with those of normal controls. Patients with LMTS showed impaired performance in word definition (compared to controls and RMTS) and in responsive naming (compared to controls). RMTS and LMTS patients performed worse than controls in word-picture matching. Both patients with left and right mesial temporal lobe epilepsy performed worse than controls in word list generation and in confrontation naming tests. Attentional-executive dysfunction may have contributed to these deficits. We conclude that patients with left and right MTS display impaired aspects of semantic knowledge. A better understanding of semantic processing difficulties in these patients will provide better insight into the difficulties with activities of daily living in this patient population. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
