The behavioural effects of levallorphan,cyprenorphine (M 285) and amphetamine on repeated Y-maze performance in rats |
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| Authors: | Samuel R. Wray Alan Cowan |
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| Affiliation: | (1) Department of Psychology, University of Hull, Hull, England;(2) Department of Pharmacology, Reckitt and Colman Limited, Hull, England |
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| Abstract: | The effects of levallorphan and cyprenorphine (M 285) were studied on repeated Y-maze performance in rats. It was postulated that these narcotic antagonists—implicated as psychotomimetics—would disrupt the experiencing process and augment fear-motivated behaviour. These compounds produced differential effects on behaviour. Levallorphan induced bizarre-excitation and disrupted habituation; cyprenorphine was ineffective in these respects. No augmentation of fear-motivated behaviour was observed. Amphetamine increased locomotor activity without affecting habituation. |
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| Keywords: | Narcotic Antagonist Psychotomimetic Habituation Activity Stress |
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