抗角蛋白单克隆抗体5 G 5对角质形成细胞增殖影响的实验研究

 目的 研究抗角蛋白单克隆抗体5G5治疗银屑病的作用机制。方法 腹腔注射乙烯雌酚有引起小鼠阴道上皮细胞增殖的作用，小鼠尾部表皮天然缺乏颗粒层，这两种特征与银屑病病理类似。不同组别的小鼠，以单抗5G5注射，观察其对角质形成细胞增殖的调节作用。结果 单抗5G5有较好的降低嗜银蛋白含量和小鼠阴道上皮细胞有丝分裂，以及促使角质形成细胞分化的作用。结论 抗角蛋白单克隆抗体5G5治疗银屑病的作用机制与调节角质形成细胞增殖有关。

Effect of anti-keratin monoclonal antibody 5 G 5 on regulating keratinocyte proliferation

Objective To study the mechanism of anti-keratin monoclonal antibody 5 G 5(5 G 5)in treating psoriasis.Methods Intraperitoneal injection of estrogen has a proliferative effect on the basal cell of mouse vagina,and the epidermis of mouse tail lacks stratum granutosum naturally.These two features are similarly identified in the pathology of psoriasis.In this experimental study,different groups of mice were fed with 5 G 5,Whose action in regulating keratinocyte proliferation was observed.Results Compared with the control group,the expression of AgNoRs and mitosis rate of the basal cells in mouse vagina decreased greatly and 5 G 5 had an ability to accelerate the formation of keratohyalin.Conclusions The mechanism of 5 G 5 in treating psoriasis may be related to regulation of keratinocyte proliferaton.