| 聚乙二醇干扰素α-2a治疗e抗原阳性慢性乙型肝炎疗效的影响因素 |
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| 引用本文： | 范荣山,徐志峰,关丽娟,孙德荣,王桂霞,王春义.聚乙二醇干扰素α-2a治疗e抗原阳性慢性乙型肝炎疗效的影响因素[J].中国实用医药,2008,3(26):45-46. |
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| 作者姓名： | 范荣山 徐志峰 关丽娟 孙德荣 王桂霞 王春义 |
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| 作者单位： | 1. 大庆市二医院肝炎二科,163461
2. 大庆市二医院肝炎检验科,163461 |
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| 摘 要： | 目的探讨聚乙二醇干扰素α-2a治疗e抗原阳性慢性乙型肝炎疗效的影响因素。方法评价性别、丙氨酸氨基转移酶、HBVDNA定量和乙肝病毒基因型对疗效的影响。结果HBV基因型为疗效影响因素,性别、丙氨酸氨基转移酶、HBVDNA定量对疗效无影响。结论基因型是聚乙二醇干扰素α-2a治疗慢性乙型肝炎疗效的影响因素。
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| 关 键 词： | 干扰素 聚乙二醇 乙型肝炎 |
Influcing factors of curative effect for peginterferon alpha 2a treating e antigen positive chronic hepatitis B patients |
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| FAN Rong-shan,XU Zhi-feng,GUAN Li-juan,et al..Influcing factors of curative effect for peginterferon alpha 2a treating e antigen positive chronic hepatitis B patients[J].China Practical Medical,2008,3(26):45-46. |
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| Authors: | FAN Rong-shan XU Zhi-feng GUAN Li-juan |
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| Institution: | FAN Rong-shan,XU Zhi-feng,GUAN Li-juan,et al.The second hospital of Daqing Heilongjiang City 163461,China |
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| Abstract: | Objective To study the influcing factors of curative effect for peginterferon alpha 2a treating e antigen positive chronic hepatitis B patients.Methods 66 patients with e antigen positive CHB received 180ug peginterferon alpha 2a every week.evaluate the influence of sex,ALT,the log value of HBVDNA,genotypes of HBV in peginterferon treating chronic hepatitis B patients.Results The sustained response(SR)rates were 68.4 percent in genotype B and 27.2 percent in genotype C group.the genotype is the influcing factor of curative factors by logistic regression.Conclusion Genotype is the influcing factor for peginterferon alpha 2a in treating e antigen positive chronic hepatitis B patients. |
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| Keywords: | Interferon Alpha 2α Hepatitis B |
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