急性脑血管病并发多器官功能衰竭患者血浆心钠素的变化

目的探讨血浆心钠素（ＡＮＰ）与急性脑血管病（ＡＣＶＤ）并发多器官功能衰竭（ＭＯＦ）的内在关系。方法采用放射免疫法测定５２例ＡＣＶＤ并或不并ＭＯＦ患者发病后第１～２天、第３～４天、第７～８天、第１５～１６天血浆ＡＮＰ的含量。结果ＡＣＶＤ后血浆ＡＮＰ含量较正常组显著降低，下降程度为并发ＭＯＦ者大于单纯ＡＣＶＤ者，其动态变化规律随ＭＯＦ发生与否而不同。结论血浆ＡＮＰ降低反映了ＡＣＶＤ后下丘脑－垂体的损伤，并参与ＭＯＦ的发生发展过程，可作为一客观指标判断ＡＣＶＤ病情及预后

Alterations in plasma concentration of atrial natriuretic polypeptide in acute cerebrovascular diseases with multiple organs failure

Objective To study the intrinsic relation between atrial natriuretic polypeptide(ANP) and acute cerebrovascular disease (ACVD)with multiple organs failure (MOF). Method Plasma ANP content of 52 cases of ACVD patients with or without MOF were radioimmunally determined at the 1st or 2nd day, 3rd or 4th day,7th day or 8th day and 15th or 16th day after onset. Result Plasma ANP content decreased significantly in ACVD. The decrease degree from high to low was that of ACVD with MOF,cerebral hemorrhage and cerebral infarction.The dynamic change regularities in ACVD and ACVD with MOF were different. Conclusion The abnormal alteration of plasma ANP content in ACVD manifested the damage of hypothalamus and pituitary and participated in the mechanism of ACVD complicated with MOF .It can be regarded as a laboratory index for judging AVCD condition and prognosis.