高嗜酸性粒细胞综合征的临床及实验室特征研究

目的 探讨高嗜酸性粒细胞综合征(HES)各亚型的临床及实验室特点,尤其是骨髓及外周血涂片中嗜酸性粒细胞的形态学特征.方法 回顾性分析该院2017-2020年63例HES患者的临床和实验室资料,复检外周血和骨髓涂片中嗜酸性粒细胞的形态学特征.结果 63例H ES患者中有反应性HES患者54例,特发性HES患者9例.反应性...

Clinical and laboratory characteristics of hypereosinophilic syndrome

Objective To investigate the clinical and laboratory characteristics of various subtypes of hypereosinophilic syndrome(HES),especially the abnormal morphological characteristics of eosinophils in bone marrow and peripheral blood smears.Methods The clinical and laboratory data of 63 patients with HES in our hospital from 2017 to 2020 were retrospectively analyzed,and the morphological characteristics of eosinophils in peripheral blood and bone marrow smears were reviewed.Results Among the 63 HES patients,54 were reactive HES patients and 9 were idiopathic HES patients.There were many etiologies in patients with reactive HES,mainly were tumors(eosinophils were non-clonal),vasculitis,infectious diseases,and drugs.The most common clinical manifestations of HES patients were rash dermatitis,with similar incidences of splenomegaly and myelofibrosis in the two groups(P>0.05).The proportion of peripheral blood eosinophils in patients with idiopathic HES was higher than that in patients with reactive HES(P<0.05).33%of idiopathic HES patients had naive eosinophils in peripheral blood,but none of reactive HES patients(P<0.05).The eosinophils in idiopathic HES patients were more likely to have abnormal morphology in bone marrow smears.The incidence of esosinophils with sparse granules,cytoplasmic basophilic granules and nuclear hyperlobation was higher in patients with idiopathic HES than in patients with reactive HES(P<0.05).Conclusion The clinical and laboratory features of idiopathic and reactive HES overlap each other,but the abnormal morphological features of eosinophils in bone marrow smears can provide some help in the differential diagnosis of the two subtypes.