与良性阵发性位置性眩晕相关的影响因素分析

目的 探讨良性阵发性位置性眩晕(BPPV)相关的影响因素.方法 选取2018年9月至2020年9月于该院神经内科就诊的BPPV患者126例作为BPPV组,选取同期年龄、性别相匹配的70例体检健康者作为对照组.记录两组人群的性别、年龄、饮酒史、吸烟史、糖尿病、高血压、家族冠心病史、偏头痛病史.检测白细胞计数(WBC)、血...

Analysis of influencing factors related to benign paroxysmal positional vertigo

Objective To investigate the influencing factors related to benign paroxysmal positional vertigo(BPPV).Methods A total of 126 BPPV patients who visited the department of Neurology in our hospital from September 2018 to September 2020 were collected as the BPPV group,and 70 cases of age-and gender-matched healthy people were selected as the control group.The gender,age,drinking history,smoking history,diabetes mellitus,hypertension,family history of coronary heart disease and migraine were recorded in the two groups.The levels of leukocyte count(WBC),platelet(Plt),hemoglobin(Hb),triacylglycerol(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),uric acid(UA),creatinine(Cr),calcium ion(Ca²⁺)and inorganic phosphorus were measured.The levels of monoamine neurotransmitters and their metabolites in serum,including norepinephrine(NE),dopamine(DA),5-hydroxytryptamine(5-HT),homovanillic acid(HVA),3-methoxy-4-hydroxyphenylethanol(MHPG),5-hydroxyindole acetic acid(5-HIAA)and 3,4-dihydroxyphenylacetic acid(DOPAC)were detected.The relationship between each index and the incidence of BPPV was explored.Results Compared with the control group,the incidence of diabetes was higher in the BPPV group,the levels of serum Ca²⁺,phosphorus,DA,NE,5-HT,DOPAC,MHPG,5-HIAA were decreased(P<0.05),and the levels of HVA were increased(P<0.05).Multivariate Logistic regression analysis showed that diabetes,Ca²⁺,inorganic phosphorus,NE,DA and 5-HT were the influencing factors of BPPV.The receiver operating characteristic curve results showed that Ca²⁺<1.89 mmol/L,DA<29.35 mg/L and 5-HT<119.4 mg/L had higher predictive value for BPPV.Conclusion The serum levels of monoamine neurotransmitters and calcium and phosphorus metabolism in BPPV patients are lower than those in healthy people,and Ca²⁺,DA,5-HT are related to the incidence of BPPV.