病原真菌基因组流行病学研究进展

基因组流行病学研究为病原真菌的遗传进化、传播和表型研究提供了新的视角, 其核心技术是全基因组测序技术和生物信息学分析, 极大地弥补了传统分子分型技术的不足。通过将病原真菌的全部遗传信息和流行病学调查相结合, 能够预测病原真菌的传播途径和传播风险, 为制定真菌防控的公共卫生策略提供理论基础。本文将对分子流行病学、基因组流行病学的发展以及基因组流行病学在病原真菌的遗传关系、溯源及进化、耐药性以及毒力、全基因组关联分析等方面的应用进行综述, 并对病原真菌基因组流行病学未来发展做出展望。

Progress in research of genomic epidemiology of pathogenic fungi

Genomic epidemiology, based on whole-genome sequencing technology and bioinformatics analysis, can make up for the shortcomings of traditional molecular typing methods and provide a novel insight for the genetic evolution and transmission of pathogenic fungi. The combination of genetic information and epidemiological methods of pathogenic fungi can predict fungi transmission routes and risks, and provide a theoretical basis for the development of public health strategies for fungi infection prevention and control. This paper summarizes the development of molecular epidemiology and genomic epidemiology, as well as the application of genomic epidemiology methods in the analyses of genetic relationship, origin, evolution, drug resistance, virulence, and genome-wide association of pathogenic fungi, and discusses the development of pathogenic fungi genomic epidemiology.