血小板衍生生长因子-AA在骨关节炎发生发展中的作用

骨关节炎是一种累及整个关节的慢性退行性疾病,它的发生、发展与软骨、软骨下骨、滑膜等组织的破坏及代谢异常存在密切关系。血小板衍生生长因子-AA(PDGF-AA)是包括软骨细胞、成骨细胞、破骨细胞、间充质干细胞在内的多种细胞重要的促有丝分裂和迁移的生长因子,能够有效地促进创伤修复。本文就软骨、软骨下骨、滑膜在骨关节炎的发展过程中的病理变化,以及PDGF-AA对这些组织及其相关细胞的作用研究进展做一综述。目前的研究已经基本阐明骨关节炎中软骨、软骨下骨、滑膜的基本病理变化,以及PDGF-AA对骨关节炎相关组织或细胞的重要调节作用,然而其内在机制仍不明确,如何将PDGF-AA运用于临床以及如何基于细胞来诊疗骨关节炎仍值得进一步研究。

The Role of Platelet-Derived Growth Factor-AA in the Pathogenesis and Development of Osteoarthritis

Osteoarthritis (OA) is a chronic degenerative disease involving the entire joint. The pathogenesis and progression of OA bear close connection to the destruction and the abnormal metabolism of cartilage, subchondral bones and synovium. Platelet derived growth factor-AA (PDGF-AA) is a critical mitogenic and chemotactic factor for a variety of cells, including chondrocytes, mesenchymal stem cells, osteoclasts and osteoblasts, and PDGF-AA promotes effective wound repair. This paper reviewed the pathological changes of cartilage, subchondral bones and synovium in the process of OA development, and summarized research progress regarding the effect of PDGF-AA on the tissues and related cells mentioned above. Current studies have basically clarified the pathological changes of cartilage, subchondral bones and synovium in OA patients, and have shown that PDGF-AA serves critical regulatory function in the tissues or cells involved in OA, the internal mechanism of which remains unclear, though. More studies should be done to find ways to apply PDGF-AA for clinic purpose and to diagnose and treat OA on the cellular basis.