病毒性心肌炎患儿血清PTX-3及IL-35水平及其与心功能、心肌损伤的相关性分析

目的 探讨病毒性心肌炎(VMC)患儿血清正五聚体蛋白-3(PTX-3)及白细胞介素(IL)-35水平及其与心功能、心肌损伤的相关性.方法 选取该院儿科收治的VMC患儿80例作为VMC组,选取同期于该院进行体检的50例健康儿童作为对照组.采用酶联免疫吸附试验比较两组血清中PTX-3、IL-35水平,采用放射免疫法检测VM...

Serum PTX-3 and IL-35 levels in children with viral myocarditis and their correlation with cardiac function and myocardial injury

Objective To investigate the serum pentameric protein-3(PTX-3)and interleukin(IL)-35 levels in children with viral myocarditis(VMC)and their correlation with cardiac function and myocardial injury.Methods A total of 80 children with VMC admitted to the pediatrics department of the hospital were selected as the VMC group,and 50 healthy children who underwent physical examination in the hospital during the same period were selected as the control group.The serum levels of PTX-3 and IL-35 in the two groups were compared by enzyme-linked immunosorbent assay,and the expression of myocardial enzymes in the VMC group was detected by radioimmunoassay.Cardiac output(CO),stroke volume(SV)and ejection fraction(EF)in VMC group was detected by ultrasound.The correlation of serum PTX-3 and IL-35 levels with myocardial enzymes and cardiac function was analyzed by Pearson correlation.Results Compared with the control group,serum PTX-3 was increased and IL-35 was decreased in the VMC group(P<0.05).Serum PTX-3 levels were positively correlated with cardiac troponin I(cTnI),creatine kinase(CK),creatine phosphokinase isoenzyme(CK-MB),alpha-hydroxybutyrate dehydrogenase(α-HBDH),aspartate aminotransferase(AST),lactate dehydrogenase(LDH,r=0.816,0.671,0.861,0.869,0.913,0.603,P<0.05),and negatively correlated with CO,SV and EF(r=-0.880,-0.836,-0.745,P<0.05).Serum IL-35 levels were negatively correlated with cTnI,CK,CK-MB,α-HBDH,AST and LDH(r=-0.539,-0.554,-0.589,-0.619,-0.531,-0.511,P<0.05),and positively correlated with CO,SV,and EF(r=0.588,0.531,0.367,P<0.05).Conclusion The level of PTX-3 in the serum of children with VMC is increased,and the level of IL-35 is decreased,and both are related to the degree of myocardial injury and cardiac function.The detection of PTX-3 and IL-35 levels has a certain clinical reference value for the diagnosis of VMC.