血浆sdLDL与缺血性脑卒中病情的相关性及预测重度卒中发生的价值分析

目的 探结论讨血浆小而密低密度脂蛋白(sdLDL)及sdLDL/低密度脂蛋白(LDL)、sdLDL/高密度脂蛋白(HDL)与缺血性脑卒中梗死面积、美国国立卫生研究院卒中量表(NIHSS)评分的关系及其预测重度卒中发生的诊断价值.方法 回顾性分析2020年4月至2021年3月就诊于福建医科大学附属泉州第一医院的272例缺...

Correlation between plasma sdLDL and ischemic stroke and its value in predicting severe stroke

Objective To investigate the relationship between plasma small and dense low-density lipoprotein(sdLDL),sdLDL/low-density lipoprotein(LDL),sdLDL/high-density lipoprotein(HDL)and ischemic stroke infarct size,national institute of health stroke scale(NIHSS)score,and its diagnostic value in predicting the occurrence of severe stroke.Methods The clinical data such as plasma sdLDL level,infarct size,NIHSS score and other clinical data of 272 patients with ischemic stroke who were treated in Quanzhou First Hospital Affiliated to Fujian Medical University from April 2020 to March 2021 were retrospectively analyzed.The plasma sdLDL,sdLDL/LDL and sdLDL/HDL of different infarct size and different NIHSS scores subgroups were compared.Spearman correlation analysis was used for the correlation of sdLDL and its ratio with NIHSS score.Receiver operating characteristic(ROC)curve was used to evaluate the value of sdLDL,sdLDL/LDL and sdLDL/HDL in predicting the occurrence of severe stroke.Results The levels of sdLDL,sdLDL/LDL and sdLDL/HDL in patients with ischemic stroke were significantly higher than those in healthy subjects,and the differences were statistically significant(P<0.05).There was no significant difference in sdLDL level,sdLDL/LDL and sdLDL/HDL among different infarct size subgroups(P>0.05).Spearman correlation analysis showed that sdLDL,sdLDL/LDL and sdLDL/HDL were not correlated with NIHSS score(r=0.074,0.028,0.030,P=0.390,0.748,0.733,respectively).The levels of sdLDL,sdLDL/LDL and sdLDL/HDL in severe stroke group were significantly higher than those in mild and moderate stroke group(P<0.05),but there was no significant difference between mild stroke group and moderate stroke group(P>0.05).The areas under the curve of sdLDL,sdLDL/LDL and sdLDL/HDL for predicting severe stroke were 0.882,0.831 and 0.849,respectively,which had good diagnostic value.Conclusion There is no correlation between plasma sdLDL and its ratio and the severity of ischemic stroke.However,the levels of sdLDL,sdLDL/LDL,and sdLDL/HDL in patients with severe stroke were significantly higher than those in patients with mild and moderate stroke,which can provide a certain reference value for clinical assessment of neurological impairment,or for the prevention of severe stroke in high-risk groups.