| The blood-brain barrier models to study apolipoprotein E genotypes in Alzheimer’s disease |
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| 作者姓名： | Irundika HK Dias Rachelle Taiwo Dan Ma |
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| 作者单位： | Aston Medical School |
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| 基金项目： | IHKD and DM would like to acknowledge funding received from Alzheimer’s Research UK West Midlands network grant 2019(to IHKD). |
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| 摘 要： | Alzheimer’s disease(AD)is a neurodegenerative disease that is characterized by an age-dependent progressive decline of memory,impairment of cognitive functions and changes in personality and behavior.Despite the improvement in understanding of the mechanisms underlying the disease,AD remains an incurable complex disorder with multifaceted pathophysiology to date.Apolipoprotein E(ApoE)is the main cholesterol carrier in the brain that supports lipid transport between brain cells.The individuals carrying the APOE4 allele are known to be at increased risk of developing AD compared with those carrying the more common APOE3 allele.
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| 关 键 词： | ALZHEIMER CHOLESTEROL IMPAIRMENT |
| 收稿时间： | 2021 Jun 30 |
The blood-brain barrier models to study apolipoprotein E genotypes in Alzheimer's disease |
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| Irundika HK Dias,Rachelle Taiwo,Dan Ma.The blood-brain barrier models to study apolipoprotein E genotypes in Alzheimer's disease[J].Neural Regeneration Research,2022,17(9):1973-1974. |
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| Authors: | Irundika HK Dias Rachelle Taiwo Dan Ma |
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| Institution: | Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham, UK |
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| Abstract: | Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by an age-dependent progressive decline of memory,impairment of cognitive function... |
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