| Chitin scaffold combined with autologous small nerve repairs sciatic nerve defects |
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| 作者姓名： | Bo Wang Chang-Feng Lu Zhong-Yang Liu Shuai Han Pi Wei Dian-Ying Zhang Yu-Hui Kou Bao-Guo Jiang |
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| 作者单位： | Department of Orthopedics and Trauma;Department of Orthopedics;National Clinical Research Center for Orthopedics |
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| 基金项目： | supported by the National Natural Science Foundation of China,Nos.31571236(to YHK),81971177(to BGJ);Key Laboratory of Trauma and Neural Regeneration(Peking University)of the Ministry of Education of China,No.BMU2020XY005-03(to BGJ);the National Key Research and Development Program of China,No.2016YFC1101604(to DYZ);the Ministry of Education Innovation Program of China,No.IRT_16R01(to BGJ);China Postdoctoral Science Foundation-Funded Project,No.2019M664007(to ZYL)。 |
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| 摘 要： | Although autologous nerve transplantation is the gold standard for treating peripheral nerve defects,it has many clinical limitations.As an alternative,various tissue-engineered nerve grafts have been developed to substitute for autologous nerves.In this study,a novel nerve graft composed of chitin scaffolds and a small autologous nerve was used to repair sciatic nerve defects in rats.The novel nerve graft greatly facilitated regeneration of the sciatic nerve and myelin sheath,reduced atrophy of the target muscle,and effectively restored neurological function.When the epineurium of the small autogenous nerve was removed,the degree of nerve regeneration was similar to that which occurs after autogenous nerve transplantation.These findings suggest that our novel nerve graft might eventually be a new option for the construction of tissue-engineered nerve scaffolds.The study was approved by the Research Ethics Committee of Peking University People's Hospital(approval No.2019 PHE27)on October 18,2019.
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| 关 键 词： | autologous small nerve chitin scaffold nerve defect nervous system peripheral nerve injury peripheral nerve regeneration sciatic nerve TRAUMA |
| 收稿时间： | 2020 Dec 26 |
Chitin scaffold combined with autologous small nerve repairs sciatic nerve defects |
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| Bo Wang,Chang-Feng Lu,Zhong-Yang Liu,Shuai Han,Pi Wei,Dian-Ying Zhang,Yu-Hui Kou,Bao-Guo Jiang.Chitin scaffold combined with autologous small nerve repairs sciatic nerve defects[J].Neural Regeneration Research,2022,17(5):1106. |
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| Authors: | Bo Wang Chang-Feng Lu Zhong-Yang Liu Shuai Han Pi Wei Dian-Ying Zhang Yu-Hui Kou Bao-Guo Jiang |
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| Institution: | 1.Department of Orthopedics and Trauma, Key Laboratory of Trauma and Neural Regeneration (Ministry of Education/Peking University), Peking University People’s Hospital, Beijing, China;2.Department of Orthopedics, Chinese PLA General Hospital, Beijing, China;3.National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing, China |
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| Abstract: | Although autologous nerve transplantation is the gold standard for treating peripheral nerve defects, it has many clinical limitations. As an alternative, various tissue-engineered nerve grafts have been developed to substitute for autologous nerves. In this study, a novel nerve graft composed of chitin scaffolds and a small autologous nerve was used to repair sciatic nerve defects in rats. The novel nerve graft greatly facilitated regeneration of the sciatic nerve and myelin sheath, reduced atrophy of the target muscle, and effectively restored neurological function. When the epineurium of the small autogenous nerve was removed, the degree of nerve regeneration was similar to that which occurs after autogenous nerve transplantation. These findings suggest that our novel nerve graft might eventually be a new option for the construction of tissue-engineered nerve scaffolds. The study was approved by the Research Ethics Committee of Peking University People''s Hospital (approval No. 2019PHE27) on October 18, 2019.Chinese Library Classification No. R456; R745; R318.08 |
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