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Sustained stress-induced changes in mice as a model for chronic depression |
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| Authors: | Natalia Elizalde Alvaro L García-García Susan Totterdell Nerea Gendive Elisabet Venzala Maria J Ramirez Joaquin Del Rio Rosa M Tordera |
| Institution: | 1. Department of Pharmacology, University of Navarra, 31080, Pamplona, Spain 2. Department of Pharmacology, University of Oxford, OX1 3QT, Oxford, UK 3. Centro investigación biomedica en Red para enfermedades neurodegenerativas (CIBERNED), Barcelona, Spain |
| Abstract: | RationaleMajor depression is a chronic disabling disorder, often preceded by stress. Despite emerging clinical interest in mechanisms perpetuating episodes of depression and/or establishing increased vulnerability for relapse, little attention has been paid to address these aspects in experimental models. Here, we studied the long-term neuroadaptive effects of chronic mild stress (CMS) as well as the effectiveness of a course of an antidepressant treatment. |
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