Involvement of Fc Receptors in Disorders of the Central Nervous System |
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Authors: | Eitan Okun Mark P Mattson Thiruma V Arumugam |
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Institution: | (1) Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 251 Bayview Boulevard, Baltimore, MD 21224, USA;(2) School of Biomedical Sciences, University of Queensland, St. Lucia, Brisbane, QLD, 4072, Australia; |
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Abstract: | Immunoglobulins are proteins with a highly variable antigen-binding domain and a constant region (Fc domain) that binds to
a cell surface receptor (FcR). Activation of FcRs in immune cells (lymphocytes, macrophages, and mast cells) triggers effector
responses including cytokine production, phagocytosis, and degranulation. In addition to their roles in normal responses to
infection or tissue injury, and in immune-related diseases, FcRs are increasingly recognized for their involvement in neurological
disorders. One or more FcRs are expressed in microglia, astrocytes, oligodendrocytes, and neurons. Aberrant activation of
FcRs in such neural cells may contribute to the pathogenesis of major neurodegenerative conditions including Alzheimer’s disease,
Parkinson’s disease, ischemic stroke, and multiple sclerosis. On the other hand, FcRs may play beneficial roles in counteracting
pathological processes; for e.g., FcRs may facilitate removal of amyloid peptides from the brain and so protect against Alzheimer’s
disease. Knowledge of the functions of FcRs in the nervous system in health and disease is leading to novel preventative and
therapeutic strategies for stroke, Alzheimer’s disease, and other neurological disorders. |
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