| PIWI、Ki-67与肿瘤关系的研究进展 |
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| 引用本文： | 刘巧,凌斌.PIWI、Ki-67与肿瘤关系的研究进展[J].医学综述,2010,16(4). |
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| 作者姓名： | 刘巧 凌斌 |
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| 作者单位： | 安徽医科大学附属省立医院,合肥,230001 |
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| 摘 要： | PIWI家族是干细胞分裂中的重要的调控基因,在干细胞的分化和肿瘤形成和发展中起着重大的作用。目前研究发现,PIWI在多种肿瘤组织中高表达,因而它可能作为肿瘤诊断和预后判断的一个新的重要指标。增殖细胞核抗原Ki-67是一种与细胞周期相关的蛋白质,它是一种核增殖标志基因,也与肿瘤的发生及发展密切相关。研究发现它们都具有抑制凋亡、促进肿瘤细胞增殖的作用。
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| 关 键 词： | PIWI Ki-67 肿瘤 |
Research Progress on the Relationship Among PIWI,Ki-67 and Tumor |
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| LIU Qiao,LING Bin.Research Progress on the Relationship Among PIWI,Ki-67 and Tumor[J].Medical Recapitulate,2010,16(4). |
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| Authors: | LIU Qiao LING Bin |
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| Institution: | LIU Qiao,LING Bin.(Anhui Provincial Hospital,Affiliated to Anhui Medical University,Hefei 230001,China) |
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| Abstract: | The gene in the PIWI family is important controlling gene in stem-cell division,it plays important role in stem cell differentiation and tumor formation.Current researches find that PIWI gene highly expresses in variety of tumors,thus it can be a useful index for the diagnosis and prognosis of tumors.Proliferating cell nuclear antigen Ki-67 is a protein which is related to cell cycle,it is a gene marking the cell nucleus proliferation,it also has close correlation with tumors generation and development.Both... |
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| Keywords: | PIWI Ki-67 |
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