An acute leukaemia augured before clinical signs by blood group antigen abnormalities and low levels of A and H blood group transferase activities in erythrocytes |
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| Authors: | M. Lopez,M. Bonnet-Gajdos,M. Reviron,&dagger D. Janvier,&dagger M. Huet,Ch.,Salmon |
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| Affiliation: | Inserm U 76, C.N.T.S. Institut, Hôpital Trousseau;Haematology Department, Hôpital Trousseau;Blood Transfusion Centre, Hôpital Saint Louis, Paris, France |
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| Abstract: | A mixed field agglutination pattern with anti-A reagents and very low levels of A and H blood group antigen specific transferase activities were found in the erythrocytes of a 4-year-old girl who presented no clinical signs of haematological disease. Blood and marrow examination displayed some features consistent with a moderate dysmyelopoietic state. 18 months later an acute myeloblastic leukaemia confirmed the suspected haematological malignancy. |
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