| 结直肠癌患者血清sP-selectin和IL-8 水平的变化及其临床意义 |
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| 引用本文： | 孟明,陈冬志.结直肠癌患者血清sP-selectin和IL-8 水平的变化及其临床意义[J].中国现代医学杂志,2003,13(23):23-25. |
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| 作者姓名： | 孟明 陈冬志 |
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| 作者单位： | 河北职工医学院基础部,保定,071000 |
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| 摘 要： | 目的 探讨结直肠癌患者手术前后血清中可溶性P -selectin和IL - 8含量的变化及其临床意义。方法 用ELISA法和RIA法分别测定结直肠癌患者手术前 ,手术后及复发病人血清sP -selectin和IL - 8的含量 ,并与对照组进行比较。结果 结直肠癌患者血清sP -selectin和IL - 8的含量明显高于正常人 (P <0 .0 1) ,术后 3个月下降至接近正常人水平 ,而复发患者则再次升高 (P <0 .0 1)。结论 血清sP -selectin和IL - 8的含量与结直肠癌的发生 ,发展及预后密切相关。
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| 关 键 词： | sP-Selectin（可溶性血小板-选择素） IL-8（白细胞介素-8） 结直肠癌 |
Changes and clinical significances of sP-selectin and IL-8 in patients with colorectal carcinoma |
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| MENG Ming and CHENG Dong-zhi Hebei Medical College for Continuing Education,Baoding,Hebei Provence.Changes and clinical significances of sP-selectin and IL-8 in patients with colorectal carcinoma[J].China Journal of Modern Medicine,2003,13(23):23-25. |
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| Authors: | MENG Ming and CHENG Dong-zhi Hebei Medical College for Continuing Education Baoding Hebei Provence |
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| Institution: | MENG Ming and CHENG Dong-zhi Hebei Medical College for Continuing Education,Baoding,Hebei Provence,071000 |
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| Abstract: | Objective:To investigate the changes and clinical significance of sP-selectin and IL-8 in patients with colorectal carcinoma before and after operation.Methods:ELISA and RIA methods were used to examine the levels of sP-selectin and IL-8 respectively before operation, after operation and after relapse.Results:The levels of sP-selectin and IL-8 in patients with colorectal carcinoma were significantly higher than those in control group (P<0.01), decreased and approached to those in control group 3 months after operation,and increased again when colorectal carcinoma relapsed (P<0.01).Conclusions:The levels of sP-selectin and IL-8 in patients with colorectal carcinoma were relative to the development and relapse of colorectal carcinoma. |
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| Keywords: | sP-selectin (soluble Platelet-selectin) IL-8 (Interleukin-8) Colorectal carcinoma |
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