首页 | 本学科首页   官方微博 | 高级检索  
     

缬沙坦对急性心肌梗死患者左室结构和功能的影响
引用本文:崔维. 缬沙坦对急性心肌梗死患者左室结构和功能的影响[J]. 中国全科医学, 2003, 6(6): 462-464
作者姓名:崔维
作者单位:450003,河南省郑州市,河南中医学院医院内二科
摘    要:目的 观察缬沙坦对急性心肌梗死 (AMI)患者左室结构和功能的影响。方法 将 72例AMI患者随机分为两组 ,常规治疗组 36例 ,口服消心痛 10mg,3次 d;缬沙坦组 36例 ,口服消心痛 10mg ,3次 d ,缬沙坦80mg ,1次 d,并于治疗后 2周、 2 4周分别进行超声心动图和平衡法核素心室造影 ,测定左室心肌重量、左室收缩和舒张功能 ,了解缬沙坦对AMI后左室重塑的阻抑作用。结果 AMI治疗 2 4周时两组患者的室间隔厚度 (IVST)、左室后壁厚度 (LVPWT)、左室舒张末内径 (LVDd)和左室心肌重量指数 (LVMI)、左室射血分数 (LVEF)、左室峰射血率时间 (LPER)、左室高峰充盈率 (LPFR)和左室高峰充盈率时间 (LTPFR)的各均值间差别均有显著性意义 (P<0 0 5 )。结论 缬沙坦能明显减轻心肌梗死后心肌肥厚和左室重塑 ,改善左室功能。

关 键 词:急性心肌梗死 缬沙坦 治疗 左室结构 舒张功能 消心痛
修稿时间:2002-09-25

Effects of Valsartan on the left ventricular structure and function following acute myocardial infarction
Cui Wei. Effects of Valsartan on the left ventricular structure and function following acute myocardial infarction[J]. Chinese General Practice, 2003, 6(6): 462-464
Authors:Cui Wei
Affiliation:Cui Wei.Department of Cardiology,Hospital of Henan Traditional Chinese Medicine College,Zhengzhou 450003
Abstract:Objective To observe effects of Valsartan on left ventricular structure and function after acute myocardial infarction(AMI).Methods A total of 72 patients with AMI were divided into two groups.36 patients were randomized to conventional treatment group with isosorbide dinitrate 10mg thrice a day,36 patients to valsartan treatment group with isosorbide dinitrate 10mg thrice a day and valsartan 80mg once a day.At 2nd week,and 24th week after AMI,the left ventricular myocardium weight were measured by echocardiogram,and the parameters of left ventricular systolic and diastolic function were measured by equilibrium radionuclide angiography.Results At 24th week,IVST,LVPWT,LVDd,LVMI,LVEF,LPER,LTPER,LPFR and LTPFR in valsartan treatment groups were significantly improved while compared with conventional treatment group.(all P<0.05 or P<0.01).Conclusion Valsartan might significantly reduce myocardial hypertrophy and left ventricular remodeling following AMI and improve the left ventricular function.
Keywords:Valsartan Acute myocardial infarction Structure and function Left ventricle
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号