层粘蛋白及受体在宫颈癌中的表达及意义

目的 探讨层粘蛋白及受体在人宫颈癌中表达及其临床意义。方法 应用SABC免疫组化法检测20例正常宫颈组织，26例宫颈原位癌，21例宫颈浸润癌Ⅰ－Ⅱ级，18例宫颈浸润癌Ⅲ级组织中层粘蛋白及受体的表达。结果 层粘蛋白在正常宫颈组织及原位癌中强表达，在宫颈浸润癌中间断或缺失，二者有显著性差异（P＜0．05）。层粘蛋白受体在正常宫颈组织及原位癌中阴性表达，在宫颈浸润癌中呈强阳性表达。有显著性差异（P＜0．05）。结论 层粘蛋白及受体在人宫颈浸润癌组织中有显著性改变，可为宫颈癌病理诊断及预后判断的标志。

Expressions and significance of laminin and laminin-receptors in human cervical carcinoma

AIM To investigate the expressions and singnificance of laminin and laminin receptors in human cervical carcinoma. METHODS Tissues from normal cervices, 26 cases with carcinoma in situ , 21 cases with microinvasive cancer and 18 cases with frankly invasive cancer were observed by SABC immunohistochemical method for expressions of laminin and laminin receptors. RESULTS The positive staining for laminin was observed in normalcervical tissues and carcinoma in situ , but was weak or abscent in cervical invasive carcinoma tissues.( P <0.05). The staining for laminin receptors of normal cervical tissues and carcinoma in situ was negative, but was positive in cervical invasive carcinoma tissues ( P <0.05). CONCLUSION There were positive changes in laminin and laminin receptors in cervical invasive carcinoma tissues. These changes may be very useful in the pathologic diagnosis and prognosis of human cervical carcinomas.