甲状腺内注射氟美松治疗亚急性甲状腺炎

目的 :观察甲状腺内注射氟美松治疗亚急性甲状腺炎的有效性和安全性。方法 :2 0例亚急性甲状腺炎患者随机分为两组 ,A组 (1 0例 )予氟美松注射液 (5mg/ml,2次 /wk)甲状腺内局部注射 ,B组口服泼尼松 (3 0mg/d) ,治疗后 2wk、4wk、8wk比较其临床结果。结果 :8wk时A组治愈率为 90 % ,B组治愈率 1 0 0 % ,两组比较无显著性差异 (P >0 2 5 )。A组疗程为 (5 6± 2 1 )wk ,B组为 (8 2±1 8)wk ,两组比较有显著性差异 (P <0 0 5 )。结论 :甲状腺局部注射氟美松治疗亚急性甲状腺炎改善症状快 ,且可以缩短疗程 ,安全有效

Theraping the patients with subacute thyroiditis in topical intrathyroid injection of dexamethasone

OBJECTIVE To investigate the efficacy and safety of topical intrathyroid injection of dexamethasone in the patients with subacute thyroiditis.METHODS Twenty patients with subacute thyroiditis were divided randomly into two groups.10 Patients (group A) were treated with topical intrathyroid injection of dexamethasone(5mg/ml,twice perweek),10 Patients (group B)were treated with prednisone 30 mg/d orally.Clinical outcomes of two groups are compared after 2 weeks,4 weeks and 8 weeks.RESULTS Curative rate of group A and group B after 8 weeks were 90% and 100% respectively and there were no significant difference(P>0.25).Duration of therapy were(5.6±2.1) weeks in group A and (8.2±1.8) weeks in group B respectively and there were significant difference (P<0.05).No adverse reactions occurred in both groups.CONCLUSIONS:Topical injection of dexamethasone in patients with subacute thyroiditis improves the symptoms rapidly and shorten the course of disease,so it is highly effective and safe.