子宫颈癌患者子宫动脉插管与静脉全身化疗两种途径新辅助化疗的效果对比

目的 比较不同途径新辅助化疗对Ⅰ b2～Ⅱ b期官颈癌的疗效.方法 对北京协和医院1999年以来收治的147例Ⅰ b2～Ⅱ b期行新辅助化疗的宫颈癌患者的临床病理资料进行同顾性分析,其中,经静脉全身化疗者(静脉组)52例,经子宫动脉插管化疗者(动脉组)95例.结果 静脉组患者经新辅助化疗后总反应率为88%(46/52),动脉组为79%(75/95),两组比较,差异无统计学意义(P>0.05).静脉组患者新辅助化疗后可手术率为81%(42/52),动脉组为72%(68/95),两组比较,差异无统计学意义(P>0.05).两组患者新辅助化疗后手术时间、出血量和并发症发生率相近.Ⅱ b期患者经新辅助化疗后手术,术后病理检查发现官旁仍有肿瘤浸润者动脉组显著低于静脉组(分别为6%、50%,P<0.05).静脉组和动脉组患者治疗后复发率(分别为13%、17%)和死亡率(分别为9%、12%,P>0.05)分别比较,差异均无统计学意义(P>0.05).结论 两种途径的新辅助化疗后反应率、可手术率及手术难度相当;子宫动脉介入化疗对改善宫旁浸润效果更好.

Comparison of effectiveness between intra-arterial and intra-venous neoadjuvant chemotherapy in stage Ⅰb2-Ⅱ b cervical carcinoma

Objective To compare the effect between intra-arterial and intra-venous neoadjuvant chemotherapy(NACT)in stage Ⅰb2-Ⅱ b cervical carcinoma.Methods A retrospective analysis Was done on 52 cases of intra-venous NACT and 95 eases of intm-arterial NACT for stage Ⅰ b2-Ⅱ b cervical carcinoma treatad in Peking Union Medical College Hospital from 1999.ResulIs The response rate of intraveHous NACT and intra-arterial NACT was 88%(46/52)and 79%(75/95).and the operative rate after NACT Was 81%(42/52)and 72%(68/95)respectively(P>0.05).There were no significant differences in surgery time,blood loss and pest-operative morbidity between these two groups.Pathological parametrial positive rate after NACT in arterial group(6%)Was significantly lower than that of venous group (50%,P>0.05).The venous group had very similar recurrence rates(13%vs 17%)and death rates (9%VS 12%)when compared with the arterial group(P>0.05).Conclusions The intra-arterial and intra-venous NACT for stage Ⅰ b2-Ⅱb cervical carcinoma show similar response rate.operative rate and surgical difficulties.Arterial NACT shows a better effect on parametrial infiltration.