| 粘细菌抗肿瘤活性次级代谢产物研究进展 |
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| 引用本文： | 鞠培殿,徐诺,王婷,刘新利.粘细菌抗肿瘤活性次级代谢产物研究进展[J].齐鲁药事,2010,29(1):38-43. |
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| 作者姓名： | 鞠培殿 徐诺 王婷 刘新利 |
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| 作者单位： | 1. 山东轻工业学院,山东省微生物工程重点实验室,山东济南250353
2. 济南宏济堂制药有限责任公司,山东济南,250100 |
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| 基金项目： | 山东省博士后创新项目专项资金 |
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| 摘 要： | 粘细菌能够产生多种次级代谢产物,这些产物具有多种生物活性和作用机理,部分次级代谢产物有很高的抗肿瘤活性,对多种肿瘤细胞有抑制作用。本文主要综述粘细菌抗肿瘤次级代谢产物(如,埃博霉素、芮唑坡丁、双萨拉唑、特吡莱辛等)的化学结构和活性研究进展。
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| 关 键 词： | 抗肿瘤 埃博霉素 芮唑坡丁 双萨拉唑 特吡莱辛 |
Progresses in myxobacterial antitumor secondary metabolites research |
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| JU Pei-dian,XU Nuo,WANG Ting,LIU Xin-li.Progresses in myxobacterial antitumor secondary metabolites research[J].qilu pharmaceutical affairs,2010,29(1):38-43. |
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| Authors: | JU Pei-dian XU Nuo WANG Ting LIU Xin-li |
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| Institution: | (Key Laboratory of Microbial Engineering,Shandong Institute ofLight Industry,Ji＇nan 250353, 1. Ji＇nan Hongjitang Pharmaceutal Co. ,Ltd. ,Ji＇nan 250100) |
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| Abstract: | Myxobacteria are extraordinary producers of secondary metabolites with various biological activities and mechanisms of action.Many of those compounds demonstrated high cytotoxicity against human tumor cells.In this paper,we summarized the structural and biological characteristics of myxobacterial secondary metabolites with the capacity of anticancer,such as,Epothilone,Rhizopodin,Disorazole,Tubulysin. |
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| Keywords: | Antitumor epothilone rhizopodin disorazole tubulysin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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