肺癌患者胸水中肿瘤标志物检测的临床意义

目的]探讨肺癌患者胸水中肿瘤标志物的检测在临床上的应用价值。方法]应用酶联免疫吸附实验（ELISA）检测170例肺癌患者和58例肺部良性疾病患者胸水中神经元特异性烯醇化酶（NSE）、胃泌素释放肽前体（pro-GRP）、细胞角蛋白19（CYFRA21-1）、鳞癌抗原（SCC）、p53抗体和CA199的水平含量。结果]肺癌患者胸水的6种肿瘤标志物水平均明显高于肺部良性疾病组,差异有统计学意义（P〈0.01）。NSE、pro-GRP在小细胞肺癌中的水平明显高于其他类型的肺癌（P〈0.01）;CYFRA21-1、鳞癌抗原（SCC）在鳞癌中的水平明显高于其他类型的肺癌（P〈0.01）。结论]胸水中6种肿瘤标志物对于肺癌的辅助诊断有一定的临床意义。

The Clinical Significance of Tumor Markers Detection in Pleural Effusion in the Patients with Lung Cancer

Purpose] To investigate the clinical significance of tumor markers in pleural effusion in the patient with lung cancer. Methods] The level of NSE,pro-GRP,CYFRA21-1,SCC,p53 antibody and CA199 in pleural effusion of 170 patients with lung cancer and 58 patients with benign lung lesion were detected by ELISA. Results] The level of the six tumor markers in patients with lung cancer was higher than that of patients with benign lung lesion （P〈0.01）.The level of NSE,pro-GRP in patients with small cell lung cancer was higher than that of other subtypes of the lung cancer（P〈0.01）. The level of the CYFRA21-1,SCC in patients with squamous carcinoma was higher than that of other subtypes of the lung cancer（P〈0.01）. Conclusion] Six tumor markers in pleural effusion have a clinical significance for assistant diagnosing lung cancer.