肺癌患者胸水中肿瘤标志物检测的临床意义 |
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引用本文: | 梁子坤,许绍发,刘志东,周世杰,宋小运.肺癌患者胸水中肿瘤标志物检测的临床意义[J].中国肿瘤,2008,17(3):249-251. |
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作者姓名: | 梁子坤 许绍发 刘志东 周世杰 宋小运 |
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作者单位: | 北京胸部肿瘤结核病医院,北京,101149 |
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摘 要: | 目的]探讨肺癌患者胸水中肿瘤标志物的检测在临床上的应用价值。方法]应用酶联免疫吸附实验(ELISA)检测170例肺癌患者和58例肺部良性疾病患者胸水中神经元特异性烯醇化酶(NSE)、胃泌素释放肽前体(pro-GRP)、细胞角蛋白19(CYFRA21-1)、鳞癌抗原(SCC)、p53抗体和CA199的水平含量。结果]肺癌患者胸水的6种肿瘤标志物水平均明显高于肺部良性疾病组,差异有统计学意义(P〈0.01)。NSE、pro-GRP在小细胞肺癌中的水平明显高于其他类型的肺癌(P〈0.01);CYFRA21-1、鳞癌抗原(SCC)在鳞癌中的水平明显高于其他类型的肺癌(P〈0.01)。结论]胸水中6种肿瘤标志物对于肺癌的辅助诊断有一定的临床意义。
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关 键 词: | 肺肿瘤 肿瘤标志物 NSE pro-GRP CYFRA21-1 SCC P53抗体 CA199 |
文章编号: | 1004-0242(2008)03-0249-03 |
修稿时间: | 2007年10月18 |
The Clinical Significance of Tumor Markers Detection in Pleural Effusion in the Patients with Lung Cancer |
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Institution: | LIANG Zi-kun,XU Shao-fa,LIU Zhi-dong,et al. (Beijing Thoracic Tumor and Tuberculosis Hospital,Beijing 101149,China) |
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Abstract: | Purpose] To investigate the clinical significance of tumor markers in pleural effusion in the patient with lung cancer. Methods] The level of NSE,pro-GRP,CYFRA21-1,SCC,p53 antibody and CA199 in pleural effusion of 170 patients with lung cancer and 58 patients with benign lung lesion were detected by ELISA. Results] The level of the six tumor markers in patients with lung cancer was higher than that of patients with benign lung lesion (P〈0.01).The level of NSE,pro-GRP in patients with small cell lung cancer was higher than that of other subtypes of the lung cancer(P〈0.01). The level of the CYFRA21-1,SCC in patients with squamous carcinoma was higher than that of other subtypes of the lung cancer(P〈0.01). Conclusion] Six tumor markers in pleural effusion have a clinical significance for assistant diagnosing lung cancer. |
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Keywords: | lung neoplasms tumor marker NSE pro-GRP CYFRA21-1 SCC p53 antibody CA199 |
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