Effect of vitamin A on hexachlorocyclohexane (HCH) toxicity in the rat. |
| |
Authors: | P Joseph T Shivanandappa K Narasimhamurthy M K Krishnakumari |
| |
Affiliation: | Toxicology Unit, Central Food Technological Research Institute, Mysore, India. |
| |
Abstract: | 1. Technical hexachlorocyclohexane (HCH) depleted hepatic stores of vitamin A in male albino rats to cause secondary vitamin A deficiency. 2. Toxicity of HCH in rats is augmented by dietary vitamin A-deficiency as evidenced by growth retardation, organ hypertrophies and alterations in the serum and liver levels of the marker enzymes of toxicity. 3. Supplementation of dietary vitamin A to the rats either in adequate (2000 IU/kg diet) or in an excess but not hypervitaminotic level (10(5) IU/kg diet) resulted in significant protection against the toxicity of HCH. 4. The activities of the hepatic xenobiotic metabolizing enzymes were generally low (with the exception of glutathione S-transferase) in the vitamin A-deficient rats compared to those of the vitamin A supplemented diet groups. 5. The results indicated that dietary vitamin A influences the response of male albino rats to HCH toxicity possibly by modulating the activities of hepatic xenobiotic metabolizing enzymes. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |