| 肾癌组织与正常肾组织Fas及其配基表达 |
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| 引用本文： | 何向阳,巫巧雄,常新,刘沙陵,安琼,杨惠娴.肾癌组织与正常肾组织Fas及其配基表达[J].实用临床医学(江西),2006,7(3):83-84. |
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| 作者姓名： | 何向阳 巫巧雄 常新 刘沙陵 安琼 杨惠娴 |
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| 作者单位： | 深圳市宝安区人民医院泌尿外科 广东深圳518101 |
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| 摘 要： | 目的:探讨Fas及其配体基因在肾癌与正常肾组织中表达的意义。方法:42例肾癌组织和13例正常肾组织采用免疫组化法检测Fas/FasL基因在肾癌与正常肾组织的表达并进行分析。结果:Fas在肾癌组织阳性表达率52.4%,明显低于正常肾组织。FasL阳性表达率54.8%,显著高于正常肾组织(P<0.05);Fas/FasL在肾癌的病理分级中表达的差异无显著性(P>0.05)。结论:Fas/FasL系统在肾癌组织中的异常表达可能参与了恶性肿瘤的形成。
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| 关 键 词： | 肾癌 Fas/FasL 凋亡 免疫组织化学 |
| 文章编号： | 1009-8194(2006)03-0083-02 |
| 收稿时间： | 12 21 2005 12:00AM |
| 修稿时间： | 2005年12月21 |
Expression of Fas and FasL in Renal Cellular Carcinoma and Controlled Normal Kidney Tissues |
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| He Xiang-yang,Wu Qiao-xiong,Chang Xin,Liu Sha-ling,An Qiong,Yang Hui-xian.Expression of Fas and FasL in Renal Cellular Carcinoma and Controlled Normal Kidney Tissues[J].Practical Clinical Medicine,2006,7(3):83-84. |
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| Authors: | He Xiang-yang Wu Qiao-xiong Chang Xin Liu Sha-ling An Qiong Yang Hui-xian |
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| Abstract: | Objective:To investigate the expressions of Fas and FasL in renal cellular carcinoma and normal renal cell.Methods:Fas and FasL expressions were assayed by means of immunohistochemical SP technique in 42 cases of renal cellular carcinomas and 13 cases of controlled normal kidney tissues.Results:Fas expression rate in renal cellular carcinomas was 52.4%,lower than that in the controlled normal kidney tissues(P<0.05),but FasL expression rate in renal cellular carcinoma was higher than that in controlled normal kidney tissue(P<0.05).There was no significantly different between the expressions of Fas and FasL in renal cell carcinoma grade(P>(0.05)).Conclusion: The abnormal expressions of Fas/FasL in renal cellular carcinoma may take part in the developing of malignant tumor. |
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| Keywords: | Renal cell carcinoma Fas/FasL immunohistochemical SP technique |
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