Effects of gammalinolenic acid on plasma lipoproteins and apolipoproteins |
| |
| Authors: | T Ishikawa Y Fujiyama O Igarashi M Morino N Tada A Kagami T Sakamoto M Nagano H Nakamura |
| |
| Affiliation: | Department of Internal Medicine, Aoto Hospital, Jikei Medical University, Tokyo, Japan. |
| |
| Abstract: | Nineteen hypercholesterolemic patients (10 without and 9 with hypertriglyceridemia) were given evening primrose oil rich in gammalinolenic acid (GLA, 18: 3n - 6), in a placebo controlled cross-over design, over 16 weeks (8 + 8 weeks), with safflower oil as the placebo. During supplementation with evening primrose oil, dihomogammalinolenic acid (20: 3n - 6) increased in plasma lipids and red blood cells, and in subjects without hypertriglyceridemia there was a significant decrease in low density lipoprotein-cholesterol and plasma apolipoprotein B compared with the levels observed during safflower oil administration. Our results confirmed that evening primrose oil is effective in lowering low density lipoprotein in hypercholesterolemic patients. |
| |
| Keywords: | |
|
|
