固脂纳米粒(SLN)药物释放系统的研究进展

目的综述固脂纳米粒作为药物释放系统的最新研究进展。方法依据近年来国内外文献资料 ,将固脂纳米粒的制备方法、药物载入、药物释放、特性分析及其在药学领域的应用情况进行了概括。结果固脂纳米粒的主要制备方法为乳化法和微乳法 ;通过调整制备工艺参数可调整药物的包封率和释药曲线 ;固脂纳米粒可供多途径给药。结论固脂纳米粒在药学领域有广阔的发展前景

Solid lipid nanoparticles (SLN) as a drug delivery system

Objective To review the new research development of the solid lipid nanoparticles as a drug delivery system.Methods According to the recent relevant literature,the production technique for the SLN,drug incorporation,drug release,characterization analysis and its application in the pharmaceutical field were summarized.Results The main production techniques of the SLN are the high pressure homogenization and microemulsion technique; the drug incorporation and release profiles can be modified as a function of production parameters;the SLN can be used by different administration routes.Conclusions The solid lipid nanoparticles have broad prospects in the pharmaceutical field.