首页 | 本学科首页   官方微博 | 高级检索  
检索        

脊髓小胶质细胞内信号p38丝裂原活化蛋白激酶在神经病理性疼痛的作用
引用本文:浦少锋,杜冬萍.脊髓小胶质细胞内信号p38丝裂原活化蛋白激酶在神经病理性疼痛的作用[J].国际麻醉学与复苏杂志,2002,30(1):285-288.
作者姓名:浦少锋  杜冬萍
作者单位:上海交通大学附属第六人民医院麻醉科,200233;
摘    要:证据表明小胶质细胞在神经病理性疼痛中扮演着重要的角色.神经损伤后,小胶质细胞内p38丝裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38MAPK)激活,致小胶质细胞产生各种生物活性物质,引发痛觉超敏.小胶质细胞内p38MAPK在神经病理性疼痛的发生和发展中起重要作用,p38MAPK及其亚型有望成为治疗神经病理性疼痛的新靶点.

关 键 词:小胶质细胞    p38丝裂原活化蛋白激酶    神经病理性疼痛    

The effect of microglial signaling p38MAPK on neuropathic pain
PU Shao-feng,DU Dong-ping.The effect of microglial signaling p38MAPK on neuropathic pain[J].international journal of anesthesiology and resuscitation,2002,30(1):285-288.
Authors:PU Shao-feng  DU Dong-ping
Abstract:Emerging evidences indicate that microglia plays a critical role in the pathogenesis of neuropathic pain. Previous evidences suggest that the activation of p38MAPK signaling pathway in hyperactive microglia in the dorsal horn of spinal cord in-volves in the neuropathic pain. Present findings shows that p38MAPK is activated in the spinal microglia after nerve injury and con-tributes importantly to the development and maintenance of neuropathic pain.
Keywords:Microgliap38MAPKNeuropathic pain
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号