夏天无总碱对豚鼠离体心肌生理特性的影响 |
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引用本文: | 刘忞,冯高闳. 夏天无总碱对豚鼠离体心肌生理特性的影响[J]. 中国药理学通报, 1989, 0(2) |
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作者姓名: | 刘忞 冯高闳 |
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作者单位: | [1]江西医学院药理教研室 [2]江西医学院药理教研室 南昌 |
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摘 要: | 采用豚鼠离体乳头状肌和心房肌标本,观察了(COAMTA)对其生理特性的影响。结果表明COAMTA 10mg/L能明显延长功能性不应期,抑制肾上腺素诱发的自律性;但不降低兴奋性,对收缩性也无明显影响。提示COAM可能具有抗心律失常的作用。
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关 键 词: | 夏天无 心房肌 乳头状肌 心肌收缩 功能性不应期 自律性 |
EFFECTS OF CORYDALIS AMABILIS MIGO TOTAL ALKALOIDS; PHYSIOLOGIC PROPERTIES OF ISOLATED GUINEA PIG MYOCARDIUM |
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Abstract: | Corydalis amabilis Migo total alkaloids (COAMTA) possessed antihypertensive and vaso-dilatative action in animal experiments. Its effects on the physiological properties in isolated guinea pig papillary muscles & atrium preparations were described in this papar.10mg/L COAMTA markedly prolonged the functional refractory period(FRP) and inhibited epinephrine induced automaticity. Suppression of normal & abnormal automaticity and prolongation of FRP may contribute to the effectiveness of COAMTA on arrhythmia. |
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Keywords: | Corydalis amabilis Migo Heart atrium Papillary muscles Myocardial contraction Functional refractory period Au-tomaticity |
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