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Detection at diagnosis of tumor cells in bone marrow aspirates of patients with small-cell lung cancer (SCLC) and clinical correlations |
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| Authors: | Pasini, F. Pelosi, G. Mostacci, R. Santo, A. Masotti, A. Spagnolli, P. Recaldin, E. Cetto, G. L. |
| Affiliation: | 1Divisione e Cattedra di Oncologia Medica, Università di Verona Verona 2Servizio di Anatomia Patologica Verona 3Divisione di Pneumologia, Ospedale Civile Maggiore Verona 4Divisione di Medicina Ospedale di Villafranca Verona 5Divisione di Geriatria Ospedale di Negrar Verona, Italy |
| Abstract: | BACKGROUND: Immunocytochemistry has often been used to identify tumor cellsin bone marrow aspirate (BMA) of SCLC patients in order to improvethe results of conventional histomorphology. However, whetherthe detection of bone marrow microlocalisation at diagnosishad implications for prognosis has not been clear. PATIENTS AND METHODS: Eighty-four slides (44 patients) and 66 bone marrow biopsies(from 42/44 patients) were evaluated. Cytospins of BMA wereincubated wih the monoclonal antibody (MAb) NCC-LU-243, recognisingthe cluster 1 antigen (NCAM) and then stained by the APAAP (alkalinephosphatase-anti-alkaline phosphatase) method. The relationshipamong BMA and PS (performance status), NSE (neuron-specificenolase), stage, survival was also studied. RESULTS: 33/84 (39%) BMA were positive for NCAM, compared with 8/66 (12%)bone marrow biopsies (p |
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